Thurnham D I, Northrop-Clewes C A, McCullough F S, Das B S, Lunn P G
Northern Ireland Centre for Diet and Health, School of Biomedical Sciences, University of Ulster, Coleraine BT 52 1SA, Northern Ireland.
J Infect Dis. 2000 Sep;182 Suppl 1:S23-8. doi: 10.1086/315912.
Gut integrity, which can be measured by the urinary lactulose:mannitol excretion test, deteriorates with the introduction of weaning foods. In The Gambia, gut integrity measured monthly over 15 months in 119 infants (aged 2-15 months) was least impaired from April to June. This coincides with the time of year of maximum vitamin A (VA) intake-the mango season. Subsequently, two VA intervention studies were done in infants in India. Eighty infants attending a community health center received 16,700 IU weekly or placebo. In another study, 94 hospitalized infants were given 200, 000 IU VA or placebo: 31 received VA on admission, while the rest (32 VA, 31 placebo) received treatment on discharge. All VA-treated groups had more rapid improvement in gut integrity than the placebo groups, but no group had gut integrity normalized by Western standards. The data suggest that VA status may influence gut integrity.
甘露醇排泄试验来衡量，随着断奶食品的引入而恶化。在冈比亚，对119名婴儿（年龄在2至15个月之间）进行了为期15个月的每月一次的肠道完整性测量，结果显示4月至6月肠道受损程度最小。这与一年中维生素A（VA）摄入量最高的时期——芒果季相吻合。随后，在印度的婴儿中进行了两项VA干预研究。80名在社区卫生中心就诊的婴儿每周接受16,700国际单位VA或安慰剂。在另一项研究中，94名住院婴儿接受了200,000国际单位VA或安慰剂：31名在入院时接受VA治疗，其余（32名VA，31名安慰剂）在出院时接受治疗。所有接受VA治疗的组在肠道完整性方面的改善都比安慰剂组更快，但没有一组的肠道完整性按照西方标准恢复正常。数据表明，VA状态可能会影响肠道完整性。
