Olukoga A, Donaldson D
East Surrey Hospital, Redhill.
J R Soc Promot Health. 2000 Jun;120(2):83-9. doi: 10.1177/146642400012000203.
This article presents an overview of the health implications of liquorice. Liquorice has beneficial applications in the medicinal and the confectionery sectors; the substance, therefore, is both widely available and commercially attractive. However, the ingestion of liquorice, and/or its active metabolites, can sometimes produce an acquired form of apparent mineralocorticoid excess (AME) syndrome, expressed as sodium retention, potassium loss and suppression of the renin-angiotensin-aldosterone system, in addition to clinical consequences such as raised blood pressure and oedema. Moreover, these metabolic changes, the mechanisms underlying which are highlighted in the accompanying text, are associated with a number of additional clinical symptoms. Considering the easy availability of liquorice itself and also of other products containing its active metabolites, it is quite possible that the health burden of liquorice-induced morbidity could be substantial. Healthcare practitioners need to be fully aware of the risks in view of a large number of reports in the literature concerning its toxicity.
本文概述了甘草对健康的影响。甘草在医药和糖果行业都有有益的应用；因此，这种物质既广泛可得又具有商业吸引力。然而，摄入甘草和/或其活性代谢产物有时会导致一种后天性的明显盐皮质激素过多（AME）综合征，表现为钠潴留、钾流失以及肾素-血管紧张素-醛固酮系统受抑制，此外还会引发如血压升高和水肿等临床后果。此外，这些代谢变化（其潜在机制在文中有突出阐述）还与许多其他临床症状相关。鉴于甘草本身以及其他含有其活性代谢产物的产品很容易获得，甘草引发疾病所带来的健康负担可能相当大。鉴于文献中有大量关于其毒性的报道，医疗从业者需要充分意识到这些风险。
