Padovan W, Meneghelli U G, Alves de Godoy R
Am J Dig Dis. 1977 Jul;22(7):618-22. doi: 10.1007/BF01073080.
In Chagas' disease, the degeneration of the nerve cells of the intramural parasympathetic ganglia of the stomach causes a wide range of motor and secretory disturbances of the organ. To assess and to correlate the alterations of these two gastric functions, electromanometric and secretory studies were performed in 22 chagasic patients and in 12 control individuals. The gastric antrum electromanometric records were carried out in basal conditions and under the stimulation of methacholine chloride (Mecholyl). Gastric secretory studies were carried out in two sessions with a Kay's test: in the first, with the test alone; in the second, associated with bethanechol chloride (Urecholine). The chagasic patients were divided into two groups according to their gastric motor response to methacholine. It was concluded that the parasympathetic denervation in Chagas' disease changes both acid and pepsin secretions in the same direction but that as the disease worsens, the responsiveness of pepsin secretion to cholinergic action tends to disappear earlier than that of acid secretion.
在恰加斯病中，胃壁内副交感神经节的神经细胞变性会导致该器官出现广泛的运动和分泌紊乱。为了评估并关联这两种胃功能的改变，对22例恰加斯病患者和12名对照个体进行了电测压和分泌研究。胃窦部的电测压记录在基础状态下以及在氯化醋甲胆碱（乙酰甲胆碱）刺激下进行。胃分泌研究分两个阶段采用凯氏试验进行：第一阶段，仅进行试验；第二阶段，与氯化氨甲酰甲胆碱（乌拉胆碱）联合进行。根据恰加斯病患者对乙酰甲胆碱的胃运动反应将其分为两组。得出的结论是，恰加斯病中的副交感神经去神经支配会使胃酸和胃蛋白酶分泌朝着相同方向改变，但随着疾病的进展，胃蛋白酶分泌对胆碱能作用的反应性往往比胃酸分泌的反应性更早消失。
