Kozel F A, Nahas Z, deBrux C, Molloy M, Lorberbaum J P, Bohning D, Risch S C, George M S
Functional Neuroimaging Division and the Brain Magnetic Stimulation Laboratories, Department of Psychiatry, Medical University of South Carolina, Charleston 29425, USA.
J Neuropsychiatry Clin Neurosci. 2000 Summer;12(3):376-84. doi: 10.1176/jnp.12.3.376.
Repetitive transcranial magnetic stimulation (rTMS) is a tool with antidepressant potential that uses a coil placed on the scalp to produce a powerful magnetic field that directly stimulates only the outermost cortex. MRI scans were obtained in 29 depressed adults involved in an rTMS antidepressant clinical treatment. These scans were analyzed to investigate the effect of distance from coil to cortex on clinical parameters. Longer motor cortex distance, but not prefrontal distance, strongly correlated with increased motor threshold (P<0.01). Clinical antidepressant response did not correlate with either distance. The rTMS antidepressant responders, however, were significantly younger (t=-2.430, P<0.05), and there appears to be a maximum threshold of age and distance to prefrontal cortex for response.
重复经颅磁刺激（rTMS）是一种具有抗抑郁潜力的工具，它使用放置在头皮上的线圈产生强磁场，该磁场仅直接刺激最外层皮质。对参与rTMS抗抑郁临床治疗的29名成年抑郁症患者进行了磁共振成像（MRI）扫描。对这些扫描结果进行分析，以研究线圈与皮质之间的距离对临床参数的影响。运动皮质距离较长，但前额叶距离并非如此，与运动阈值增加密切相关（P<0.01）。临床抗抑郁反应与这两种距离均无相关性。然而，rTMS抗抑郁反应者明显更年轻（t=-2.430，P<0.05），并且似乎存在对前额叶皮质反应的年龄和距离的最大阈值。
