果蝇中碱性螺旋-环-螺旋因子的全基因组调查。
A genomewide survey of basic helix-loop-helix factors in Drosophila.
作者信息
Moore A W, Barbel S, Jan L Y, Jan Y N
机构信息
Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143-0725, USA.
出版信息
Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10436-41. doi: 10.1073/pnas.170301897.
Abstract
The basic helix-loop-helix (bHLH) transcription factors play important roles in the specification of tissue type during the development of animals. We have used the information contained in the recently published genomic sequence of Drosophila melanogaster to identify 12 additional bHLH proteins. By sequence analysis we have assigned these proteins to families defined by Atonal, Hairy-Enhancer of Split, Hand, p48, Mesp, MYC/USF, and the bHLH-Per, Arnt, Sim (PAS) domain. In addition, one single protein represents a unique family of bHLH proteins. mRNA in situ analysis demonstrates that the genes encoding these proteins are expressed in several tissue types but are particularly concentrated in the developing nervous system and mesoderm.
摘要
基本螺旋-环-螺旋（bHLH）转录因子在动物发育过程中的组织类型特化中发挥着重要作用。我们利用最近发表的黑腹果蝇基因组序列中的信息，鉴定出另外12种bHLH蛋白。通过序列分析，我们将这些蛋白归入由无调性、毛状分裂增强子、手、p48、中胚层后轴中胚层决定因子、MYC/USF以及bHLH-Per、芳香烃受体核转运蛋白、单一-minded（PAS）结构域所定义的家族。此外，有一种单一蛋白代表了一个独特的bHLH蛋白家族。mRNA原位分析表明，编码这些蛋白的基因在几种组织类型中表达，但特别集中在发育中的神经系统和中胚层。
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