小鼠胸腺基质淋巴细胞生成素（TSLP）受体的克隆：功能性异源复合物的形成需要白细胞介素7受体。

Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor.

作者信息

Park L S, Martin U, Garka K, Gliniak B, Di Santo J P, Muller W, Largaespada D A, Copeland N G, Jenkins N A, Farr A G, Ziegler S F, Morrissey P J, Paxton R, Sims J E

机构信息

Department of Biochemistry, Immunex Corporation, Seattle, Washington 98101, USA.

出版信息

J Exp Med. 2000 Sep 4;192(5):659-70. doi: 10.1084/jem.192.5.659.

The cellular receptor for murine thymic stromal lymphopoietin (TSLP) was detected in a variety of murine, but not human myelomonocytic cell lines by radioligand binding. cDNA clones encoding the receptor were isolated from a murine T helper cell cDNA library. TSLP receptor (TSLPR) is a member of the hematopoietin receptor family. Transfection of TSLPR cDNA resulted in only low affinity binding. Cotransfection of the interleukin 7 (IL-7)Ralpha chain cDNA resulted in conversion to high affinity binding. TSLP did not activate cells from IL-7Ralpha(-/)- mice, but did activate cells from gammac(-/)- mice. Thus, the functional TSLPR requires the IL-7Ralpha chain, but not the gammac chain for signaling.