van Dam R M, Visscher A W, Feskens E J, Verhoef P, Kromhout D
Department of Chronic Diseases Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
Eur J Clin Nutr. 2000 Sep;54(9):726-31. doi: 10.1038/sj.ejcn.1601086.
To examine whether a high dietary glycemic index is associated with hyperinsulinemia, hyperglycemia, dyslipidemia and coronary heart disease (CHD) risk in elderly men.
Prospective study of incidence of major CHD (non-fatal myocardial infarction or death due to CHD) between 1985 and 1995 in 646 men, and a cross-sectional analysis of metabolic risk factors in 1990 in 394 men.
Population based study in the Dutch town Zutphen.
Men aged 64-84 y in 1985 without a history of CHD or diabetes, whose diet was assessed with the cross-check dietary history method.
The dietary glycemic index was positively correlated with consumption (g carbohydrate) of wheat bread (r=0.47) and sugar products (r=0.41) and inversely with fruit (r=-0.37) and milk (r=-0.40) consumption. During 4527 person-years of follow-up, 94 cases of CHD were documented. The risk ratio for CHD was 1.11 (95% CI, 0.66-1.87) for the highest as compared to the lowest tertile of glycemic index after correction for age, body mass index, physical activity, cigarette smoking, and dietary factors (P (trend)=0.70). Furthermore, the glycemic index was not appreciably associated with blood concentrations of total cholesterol, HDL-cholesterol, triacylglycerols or (fasting or postload) insulin or glucose.
Our findings do not support the hypothesis that a high-glycemic-index diet unfavorably affects metabolic risk factors or increases risk for CHD in elderly men without a history of diabetes or CHD.
研究高膳食血糖生成指数是否与老年男性的高胰岛素血症、高血糖、血脂异常及冠心病（CHD）风险相关。
对646名男性在1985年至1995年间主要冠心病（非致命性心肌梗死或因冠心病死亡）发病率进行前瞻性研究，并对394名男性在1990年的代谢危险因素进行横断面分析。
荷兰祖特芬镇基于人群的研究。
1985年年龄在64 - 84岁、无冠心病或糖尿病病史的男性，其饮食通过交叉核对饮食史方法进行评估。
膳食血糖生成指数与小麦面包（r = 0.47）和糖制品（r = 0.41）的摄入量（克碳水化合物）呈正相关，与水果（r = -0.37）和牛奶（r = -0.40）的摄入量呈负相关。在4527人年的随访期间，记录了94例冠心病病例。在校正年龄、体重指数、体力活动、吸烟和饮食因素后，血糖生成指数最高三分位数组与最低三分位数组相比，冠心病风险比为1.11（95%可信区间，0.66 - 1.87）（P（趋势）= 0.70）。此外，血糖生成指数与总胆固醇、高密度脂蛋白胆固醇、三酰甘油或（空腹或餐后）胰岛素或血糖的血浓度无明显关联。
我们的研究结果不支持高血糖生成指数饮食对无糖尿病或冠心病病史的老年男性的代谢危险因素产生不利影响或增加冠心病风险这一假设。
