Shimaoka Y, Hidaka Y, Tada H, Nakamura T, Mitsuda N, Morimoto Y, Murata Y, Amino N
Department of Laboratory Medicine, Osaka University Medical School, Suita, Japan.
Am J Reprod Immunol. 2000 Sep;44(3):143-7. doi: 10.1111/j.8755-8920.2000.440303.x.
The systemic T helper 1/T helper 2 (Th1/Th2) cytokine balance during normal human pregnancy is controversial, and observations about the balance in the postpartum period have only been reported for up to 3 months.
Whole-blood, from 83 healthy pregnant women, 80 healthy postpartum women, and 31 healthy non-pregnant women was stimulated with phorbol 12-myristate 13-acetate (PMA) and ionomycin, and the levels of cytokines in the supernatant were measured by enzyme-linked immunosorbent assay (ELISA).
The production of all measured cytokines decreased during pregnancy, especially in the second trimester. After delivery, interferon-gamma (IFN-gamma) and interleukin-2 (IL-2) increased from 2 to 11 months postpartum, and IL-4 increased from 6 to 11 months postpartum.
These data indicate that 1) decreases in production of both Th1-and Th2-type cytokines during pregnancy may be related to the pregnancy-induced amelioration of autoimmune diseases: 2) increases in production of both Th1- and Th2-type cytokines in the postpartum period may be related to the postpartum aggravation of autoimmune diseases.
正常人类孕期全身辅助性T细胞1/辅助性T细胞2（Th1/Th2）细胞因子平衡存在争议，且关于产后时期该平衡的观察仅报道至产后3个月。
用佛波酯12 - 肉豆蔻酸酯13 - 乙酸酯（PMA）和离子霉素刺激83名健康孕妇、80名健康产后妇女和31名健康非孕妇女的全血，通过酶联免疫吸附测定（ELISA）测量上清液中细胞因子的水平。
孕期所有检测细胞因子的产生均减少，尤其在孕中期。分娩后，产后2至11个月时干扰素 - γ（IFN - γ）和白细胞介素 - 2（IL - 2）增加，产后6至11个月时IL - 4增加。
这些数据表明：1）孕期Th1型和Th2型细胞因子产生均减少可能与孕期诱导的自身免疫性疾病改善有关；2）产后Th1型和Th2型细胞因子产生增加可能与产后自身免疫性疾病加重有关。
