头孢他啶对大鼠全身细胞因子浓度的影响。
Effect of ceftazidime on systemic cytokine concentrations in rats.
作者信息
Alkharfy K M, Kellum J A, Frye R F, Matzke G R
机构信息
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
出版信息
Antimicrob Agents Chemother. 2000 Nov;44(11):3217-9. doi: 10.1128/AAC.44.11.3217-3219.2000.
Abstract
The effect of a single dose of ceftazidime on circulating concentrations of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) in a rat model of sepsis was studied. IL-6 concentrations were significantly elevated (100 to 200 times the baseline) 6 h after ceftazidime administration in both septic and nonseptic (control) rats. TNF-alpha concentrations increased significantly in nonseptic (approximately 40 times the baseline) rats but not septic (approximately 2 to 3 times the baseline) rats. Ceftazidime administration was not associated with an increase in endotoxin concentrations. These findings suggest that ceftazidime modulation of proinflammatory cytokine concentrations may be independent of its antimicrobial properties.
摘要
研究了单剂量头孢他啶对脓毒症大鼠模型中白细胞介素-6（IL-6）和肿瘤坏死因子α（TNF-α）循环浓度的影响。在给予头孢他啶6小时后，脓毒症大鼠和非脓毒症（对照）大鼠的IL-6浓度均显著升高（为基线的100至200倍）。非脓毒症大鼠的TNF-α浓度显著增加（约为基线的40倍），而脓毒症大鼠的TNF-α浓度未显著增加（约为基线的2至3倍）。给予头孢他啶与内毒素浓度升高无关。这些发现表明，头孢他啶对促炎细胞因子浓度的调节可能与其抗菌特性无关。
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本文引用的文献
1
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Infection. 1998 Mar-Apr;26(2):77-84. doi: 10.1007/BF02767765.
2
Tumor necrosis factor alpha and interleukin 6 release induced by antibiotic killing of Pseudomonas aeruginosa and Staphylococcus aureus.抗生素杀死铜绿假单胞菌和金黄色葡萄球菌所诱导的肿瘤坏死因子α和白细胞介素6释放
Eur J Clin Microbiol Infect Dis. 1997 Jun;16(6):467-71. doi: 10.1007/BF02471914.
3
Sepsis and serum cytokine concentrations.脓毒症与血清细胞因子浓度
Crit Care Med. 1997 Mar;25(3):405-12. doi: 10.1097/00003246-199703000-00006.
4
Immunomodulating effects of antibiotics: literature review.抗生素的免疫调节作用：文献综述
Infection. 1996 Jul-Aug;24(4):275-91. doi: 10.1007/BF01743360.
5
Pattern of cytokines and pharmacomodulation in sepsis induced by cecal ligation and puncture compared with that induced by endotoxin.与内毒素诱导的脓毒症相比，盲肠结扎穿孔诱导的脓毒症中细胞因子模式及药物调节作用
Clin Diagn Lab Immunol. 1995 Sep;2(5):549-53. doi: 10.1128/cdli.2.5.549-553.1995.
6
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Diagn Microbiol Infect Dis. 1993 Mar-Apr;16(3):185-9. doi: 10.1016/0732-8893(93)90109-k.
7
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Drugs. 1995 Apr;49(4):577-617. doi: 10.2165/00003495-199549040-00008.
9
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Infect Immun. 1995 Jun;63(6):2236-42. doi: 10.1128/iai.63.6.2236-2242.1995.
10
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J Infect Dis. 1995 Sep;172(3):886-91. doi: 10.1093/infdis/172.3.886.
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