蛋白质溶液核磁共振波谱法同位素标记策略的新进展。
New developments in isotope labeling strategies for protein solution NMR spectroscopy.
作者信息
Goto N K, Kay L E
机构信息
Department of Biochemistry, University of Toronto, M5S 1A8, Toronto, Ontario, Canada.
出版信息
Curr Opin Struct Biol. 2000 Oct;10(5):585-92. doi: 10.1016/s0959-440x(00)00135-4.
Abstract
The development of novel isotope labeling strategies for proteins has facilitated the study of the structure and dynamics of these molecules. In addition, the recent emergence of alternative methods of bacterial expression for obtaining isotopically labeled proteins permits the study of new classes of important proteins by solution NMR methods.
摘要
用于蛋白质的新型同位素标记策略的发展促进了对这些分子的结构和动力学的研究。此外，最近出现的用于获得同位素标记蛋白质的细菌表达替代方法使得通过溶液核磁共振方法研究新的重要蛋白质类别成为可能。
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