Tan M, Parkin J E
School of Pharmacy, Curtin University of Technology, G.P.O. Box U 1987, WA 6845, Perth, Australia.
Int J Pharm. 2000 Nov 4;208(1-2):23-34. doi: 10.1016/s0378-5173(00)00514-7.
The route of formation and identification of the principal degradation products of thimerosal (thiomersal) has been undertaken. The initial oxidation to dithiosalicylic acid is followed by cleavage of the disulphide bond of the dithiosalicylic acid by the ethylmercuric ion to reform 1.5 mol of thimerosal with concurrent oxidation to form 0.5 mol of 2-sulfinobenzoic acid for each mole of dithiosalicylic acid. In the presence of copper ions 2-sulfobenzoic acid was also formed. A mechanism has been proposed which accounts for the stoichiometry of the cleavage reaction observed and the significance of the reaction is discussed.
已对硫柳汞（硫柳酸汞）主要降解产物的形成途径和鉴定方法进行了研究。最初氧化生成二硫代水杨酸，随后二硫代水杨酸的二硫键被乙基汞离子裂解，重新生成1.5摩尔硫柳汞，同时每摩尔二硫代水杨酸氧化生成0.5摩尔2-亚磺基苯甲酸。在铜离子存在的情况下，也会生成2-磺基苯甲酸。已提出一种机制，该机制解释了所观察到的裂解反应的化学计量关系，并讨论了该反应的意义。
