肝脏吞噬作用受抑制后抗体产生增加。
Increased antibody production following depression of hepatic phagocytosis.
作者信息
Souhami R L, Addison I E, Bradfield J W
出版信息
Clin Exp Immunol. 1975 Apr;20(1):155-9.
Abstract
The influence of Kupffer cell blockade on the humoral immune response to suboptimal doses of intravenous sheep red blood cells has been measured in mice. Hepatic phagocytosis was suppressed using dextran sulphate. Direct (IgM) and indirect (IgG) plaque-forming cells were measured in spleens from treated and untreated mice at varying times after the antigen. The results show that after Kupffer cell blockade both IgM and IgG responses correspond to the responses seen after a 10-fold greater dose of cells in control animals. The implications of this are discussed.
摘要
在小鼠中测量了库普弗细胞阻断对次优剂量静脉注射绵羊红细胞体液免疫反应的影响。使用硫酸葡聚糖抑制肝脏吞噬作用。在给予抗原后的不同时间，测量处理组和未处理组小鼠脾脏中的直接（IgM）和间接（IgG）斑块形成细胞。结果表明，在库普弗细胞阻断后，IgM和IgG反应与对照动物中给予10倍剂量细胞后所见的反应相当。讨论了其意义。
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Increased antibody production following depression of hepatic phagocytosis.肝脏吞噬作用受抑制后抗体产生增加。
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The production of antibody by patients with chronic hepatic disease.慢性肝病患者抗体的产生。
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Control of spillover. The importance of Kupffer-cell function in clinical medicine.溢出控制。库普弗细胞功能在临床医学中的重要性。
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