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1
Increased antibody production following depression of hepatic phagocytosis.肝脏吞噬作用受抑制后抗体产生增加。
Clin Exp Immunol. 1975 Apr;20(1):155-9.
2
The recovery of hepatic phagocytosis after blockade of Kupffer cells.
J Reticuloendothel Soc. 1974 Aug;16(2):75-86.
3
Regulation of immunoglobulin synthesis by dextran.右旋糖酐对免疫球蛋白合成的调节
J Exp Med. 1973 Jul 1;138(1):176-93. doi: 10.1084/jem.138.1.176.
4
Stimulation of humoral antibody formation by polyanions. 3. Restoration of the immune response to sheep red blood cells by polyanions in thymectomized and lethally irradiated mice protected with bone marrow cells.多聚阴离子对体液抗体形成的刺激作用。3. 多聚阴离子对经胸腺切除和致死性照射并用骨髓细胞保护的小鼠体内针对绵羊红细胞免疫反应的恢复作用。
Eur J Immunol. 1971 Aug;1(4):302-4. doi: 10.1002/eji.1830010418.
5
Inhibition of the immune response of mouse spleen cells to sheep erythrocytes in vitro by anti-immunoglobulin sera.抗免疫球蛋白血清对小鼠脾细胞体外抗绵羊红细胞免疫反应的抑制作用。
Eur J Immunol. 1971 Jun;1(3):157-62. doi: 10.1002/eji.1830010303.
6
The immune response of mice treated with anti-mu antibodies: the effect on antibody-forming cells, their precursors and helper cells assayed in vitro.用抗μ抗体处理的小鼠的免疫反应：对体外测定的抗体形成细胞、其前体和辅助细胞的影响。
J Immunol. 1975 Jun;114(6):1808-12.
7
Alloimmune hemolytic plaque-forming cells: kinetics of IgM and IgG alloantibody releasing cells during a primary and secondary immune response of chickens.同种免疫溶血空斑形成细胞：鸡初次和二次免疫应答过程中IgM和IgG同种抗体释放细胞的动力学
J Immunol. 1972 Aug;109(2):207-12.
8
Effects of oestrogens and pregnancy on the distribution of sheep erythrocytes and the antibody response in mice.雌激素和妊娠对绵羊红细胞分布及小鼠抗体反应的影响。
Clin Exp Immunol. 1975 Apr;20(1):179-86.
9
Immunoglobulin classes of antibody-forming cells in mice. 3. Immunoglobulin antibody restriction of plaque-forming cells demonstrated by the double immunofluorescent technique.小鼠中抗体形成细胞的免疫球蛋白类别。3. 用双重免疫荧光技术证明的噬斑形成细胞的免疫球蛋白抗体限制。
J Immunol. 1970 Apr;104(4):976-83.
10
Stimulation of humoral antibody formation by polyanions. IV. The effects of dextran sulfate on the kinetics of secondary immune response in mice.多聚阴离子对体液抗体形成的刺激作用。IV. 硫酸葡聚糖对小鼠二次免疫应答动力学的影响。
Eur J Immunol. 1971 Dec;1(6):426-9. doi: 10.1002/eji.1830010604.

引用本文的文献

1
Effect of isolated portal hypertension on Kupffer cell function.孤立性门静脉高压对库普弗细胞功能的影响。
Dig Dis Sci. 1994 Jan;39(1):46-50. doi: 10.1007/BF02090059.
2
The surface properties and antigen-presenting function of hepatic non-parenchymal cells.肝脏非实质细胞的表面特性及抗原呈递功能。
Clin Exp Immunol. 1981 Dec;46(3):581-8.
3
Effect of carrageenan on activity of the mononuclear phagocyte system in the mouse.角叉菜胶对小鼠单核吞噬细胞系统活性的影响。
Br J Exp Pathol. 1978 Apr;59(2):213-9.
4
Autoantibodies detected in rabbits hyperimmunized with group A, C, and G streptococcal vaccines.在A、C和G组链球菌疫苗超免疫的兔子中检测到自身抗体。
Infect Immun. 1977 Dec;18(3):624-8. doi: 10.1128/iai.18.3.624-628.1977.
5
Correlation between hepatic morphology and immunoglobulins and antibodies to Escherichia coli in cirrhosis.肝硬化患者肝脏形态与免疫球蛋白及抗大肠杆菌抗体之间的相关性
Gut. 1977 Jan;18(1):28-32. doi: 10.1136/gut.18.1.28.
6
Influence of reticuloendothelial blockade on the induction of tolerance and immunity by polysaccharides.网状内皮系统阻断对多糖诱导耐受和免疫的影响。
Immunology. 1976 Feb;30(2):221-7.

本文引用的文献

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The production of antibody by patients with chronic hepatic disease.慢性肝病患者抗体的产生。
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2
The half-life of I131 labeled normal human gamma globulin in patients with hepatic cirrhosis.肝硬化患者中I131标记的正常人γ球蛋白的半衰期。
J Immunol. 1954 Oct;73(4):256-8.
3
Antibody production studied by means of the LHG assay. I. The splenic response of CBA mice to sheep erythrocytes.通过淋巴细胞转化试验研究抗体产生。I. CBA小鼠对绵羊红细胞的脾脏反应。
Immunology. 1966 Dec;11(6):603-16.
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The 198-Au liver scan. An index of portal-systemic collateral circulation in chronic liver disease.
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The actvity of mouse Kupffer cells following intravenous injection of T4 bacteriophage.静脉注射T4噬菌体后小鼠库普弗细胞的活性。
Clin Exp Immunol. 1969 Jul;5(1):173-87.
6
Differential sensitivity of haemolytic plaque methods at various stages of the immune response.溶血空斑法在免疫反应不同阶段的差异敏感性。
Cell Immunol. 1971 Feb;2(1):13-40. doi: 10.1016/0008-8749(71)90023-2.
7
The mechanism of the adjuvant effect of dextran sulphate.硫酸葡聚糖的佐剂效应机制。
Immunology. 1974 Feb;26(2):383-92.
8
The effect of colloidal carbon on the organ distribution of sheep red cells and the immune response.胶体碳对绵羊红细胞器官分布及免疫反应的影响。
Immunology. 1972 Apr;22(4):685-94.
9
Control of spillover. The importance of Kupffer-cell function in clinical medicine.溢出控制。库普弗细胞功能在临床医学中的重要性。
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10
Gammopathy in liver disease.
Prog Liver Dis. 1972;4:403-17.

肝脏吞噬作用受抑制后抗体产生增加。

Increased antibody production following depression of hepatic phagocytosis.

作者信息

Souhami R L, Addison I E, Bradfield J W

出版信息

Clin Exp Immunol. 1975 Apr;20(1):155-9.

PMID:1106919
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1538176/
Abstract

The influence of Kupffer cell blockade on the humoral immune response to suboptimal doses of intravenous sheep red blood cells has been measured in mice. Hepatic phagocytosis was suppressed using dextran sulphate. Direct (IgM) and indirect (IgG) plaque-forming cells were measured in spleens from treated and untreated mice at varying times after the antigen. The results show that after Kupffer cell blockade both IgM and IgG responses correspond to the responses seen after a 10-fold greater dose of cells in control animals. The implications of this are discussed.

摘要

在小鼠中测量了库普弗细胞阻断对次优剂量静脉注射绵羊红细胞体液免疫反应的影响。使用硫酸葡聚糖抑制肝脏吞噬作用。在给予抗原后的不同时间，测量处理组和未处理组小鼠脾脏中的直接（IgM）和间接（IgG）斑块形成细胞。结果表明，在库普弗细胞阻断后，IgM和IgG反应与对照动物中给予10倍剂量细胞后所见的反应相当。讨论了其意义。