Puoti M, Bonacini M, Spinetti A, Putzolu V, Govindarajan S, Zaltron S, Favret M, Callea F, Gargiulo F, Donato F, Carosi G
Clinica di Malattie Infettive e Tropicali, Spedali Civili, Piazza Ospedale 1, I-25123 Brescia, Italy.
J Infect Dis. 2001 Jan 1;183(1):134-7. doi: 10.1086/317644. Epub 2000 Nov 16.
A total of 204 patients with liver biopsy-proven hepatitis C virus (HCV) infection, 84 with and 120 without human immunodeficiency virus (HIV) coinfection, were studied, to evaluate variables possibly associated with the stage of liver fibrosis. All patients were injection drugs users, with a mean age of 32 years and an estimated duration of HCV infection of 12 years. Twenty-four patients (11%) had many fibrous septa with (5%) or without (6%) cirrhosis, 56 (27%) had few fibrous septa, and 124 (60%) had no fibrous septa. In all patients, an association was found between CD4 cell counts <500 cells/mm(3)and the presence of many fibrous septa (odds ratio, 3.2; P=.037), independent of HIV infection and other factors. These results suggest that HIV infection-induced CD4 depletion is independently associated with the severity of liver fibrosis in chronic HCV infection.
共研究了204例经肝活检证实为丙型肝炎病毒（HCV）感染的患者，其中84例合并人类免疫缺陷病毒（HIV）感染，120例未合并HIV感染，以评估可能与肝纤维化阶段相关的变量。所有患者均为注射吸毒者，平均年龄32岁，估计HCV感染持续时间为12年。24例患者（11%）有许多纤维间隔，其中5%伴有肝硬化，6%不伴有肝硬化；56例（27%）有少量纤维间隔；124例（60%）无纤维间隔。在所有患者中，发现CD4细胞计数<500个细胞/mm³与存在许多纤维间隔相关（优势比为3.2；P = 0.037），且独立于HIV感染和其他因素。这些结果表明，HIV感染引起的CD4细胞减少与慢性HCV感染中肝纤维化的严重程度独立相关。
