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用卡那霉素气雾剂治疗小鼠呼吸道肺炎克雷伯菌感染。

Treatment of respiratory Klebsiella pneumoniae infection in mice with aerosols of kanamycin.

作者信息

Berendt R F, Long G G, Walker J S

出版信息

Antimicrob Agents Chemother. 1975 Nov;8(5):585-90. doi: 10.1128/AAC.8.5.585.

DOI:10.1128/AAC.8.5.585
PMID:1108778
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429426/
Abstract

Aerosols of kanamycin resulted in greater survival of mice challenged with respiratory Klebsiella pneumoniae than the same dosage given intramuscularly. Determinations of viable bacteria in the blood and lungs revealed that aerosolized kanamycin was most effective when infection was confined to the lungs. After the organisms had spread to other areas, however, aerosol therapy was still more effective than intramuscular therapy, but only one-half the infected mice survived.

摘要

与肌肉注射相同剂量的卡那霉素相比，雾化吸入卡那霉素可使受到呼吸道肺炎克雷伯菌攻击的小鼠存活率更高。对血液和肺部活菌的测定表明，当感染局限于肺部时，雾化吸入的卡那霉素最为有效。然而，在细菌扩散到其他部位后，雾化治疗仍然比肌肉注射治疗更有效，但只有一半的感染小鼠存活下来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a46/429426/1b7ba72c25d5/aac00329-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a46/429426/1b7ba72c25d5/aac00329-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a46/429426/1b7ba72c25d5/aac00329-0081-a.jpg

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本文引用的文献

1
An apparatus for the study of airborne infection.一种用于研究空气传播感染的装置。
J Hyg (Lond). 1952 Mar;50(1):53-68. doi: 10.1017/s0022172400019422.
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SINGLE-STAGE IMPACTION DEVICE FOR PARTICLE SIZING BIOLOGICAL AEROSOLS.用于生物气溶胶颗粒大小测定的单级撞击装置。
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[Comparative study of the effect of inhalation and subcutaneous methods of administration of kanamycin during treatment and prevention of experimental pneumonia in albino mice].[卡那霉素吸入与皮下给药方法在治疗和预防白化小鼠实验性肺炎中的效果比较研究]
肠螯合素的钪和铟配合物对肺炎克雷伯菌的抗菌作用
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Experimental model of Klebsiella infection in mice for studies on mechanisms of local immunity of the respiratory tract.用于研究呼吸道局部免疫机制的小鼠克雷伯菌感染实验模型。
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In vitro and in vivo morphological response of Klebsiella pneumoniae to cefotiam and cefazolin.肺炎克雷伯菌对头孢替安和头孢唑林的体外及体内形态学反应
Antimicrob Agents Chemother. 1981 May;19(5):901-10. doi: 10.1128/AAC.19.5.901.
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Pentamidine aerosol in prophylaxis and treatment of murine Pneumocystis carinii pneumonia.喷他脒气雾剂在预防和治疗小鼠卡氏肺孢子虫肺炎中的应用
Antimicrob Agents Chemother. 1987 Jul;31(7):978-81. doi: 10.1128/AAC.31.7.978.
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Continuous aerosol therapy system using a modified Collison nebulizer.使用改良型科里森雾化器的连续气溶胶治疗系统。
J Clin Microbiol. 1977 Feb;5(2):131-6. doi: 10.1128/jcm.5.2.131-136.1977.
8
Changes in whole blood and serum components of grivet monkeys with experimental respiratory Francisella tularensis infection.实验性呼吸道土拉热弗朗西斯菌感染的埃及狒狒全血和血清成分的变化
Br J Exp Pathol. 1978 Dec;59(6):630-9.
9
Nonhuman primate model for the study of respiratory Klebsiella pneumoniae infection.用于研究呼吸道肺炎克雷伯菌感染的非人灵长类动物模型。
Infect Immun. 1978 Oct;22(1):275-81. doi: 10.1128/iai.22.1.275-281.1978.
10
Relationship of method of administration to respiratory virulence of Klebsiella pneumoniae for mice and squirrel monkeys.肺炎克雷伯菌对小鼠和松鼠猴的给药方法与呼吸道毒力的关系。
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4
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Ann N Y Acad Sci. 1966 Jun 14;132(2):870-8. doi: 10.1111/j.1749-6632.1966.tb43007.x.
5
Pulmonary absorption and retention of kanamycin after repeated inhalation administration of kanamycin aerosol.反复吸入卡那霉素气雾剂后卡那霉素在肺部的吸收与潴留
Appl Microbiol. 1970 Apr;19(4):583-5. doi: 10.1128/am.19.4.583-585.1970.
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Bacterial colonization and clinical superinfection of the respiratory tract complicating antibiotic treatment of pneumonia.呼吸道细菌定植及临床二重感染使肺炎的抗生素治疗复杂化。
J Infect Dis. 1969 Jun;119(6):597-624. doi: 10.1093/infdis/119.6.597.
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Pseudomonas aeruginosa pneumonia in adults.成人铜绿假单胞菌肺炎
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Aerosol therapy in acute and chronic respiratory disease.急慢性呼吸道疾病的雾化治疗
Arch Intern Med. 1973 Jan;131(1):148-55.
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Am Rev Respir Dis. 1973 Nov;108(5):1130-40. doi: 10.1164/arrd.1973.108.5.1130.