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本文引用的文献

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Cryptosporidium systematics and implications for public health.隐孢子虫的系统分类及其对公共卫生的影响。
Parasitol Today. 2000 Jul;16(7):287-92. doi: 10.1016/s0169-4758(00)01699-9.
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Molecular and phylogenetic analysis of Cryptosporidium muris from various hosts.来自不同宿主的微小隐孢子虫的分子和系统发育分析。
Parasitology. 2000 May;120 ( Pt 5):457-64. doi: 10.1017/s0031182099005703.
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Phylogenetic relationships of Cryptosporidium parasites based on the 70-kilodalton heat shock protein (HSP70) gene.基于70千道尔顿热休克蛋白（HSP70）基因的隐孢子虫寄生虫的系统发育关系。
Appl Environ Microbiol. 2000 Jun;66(6):2385-91. doi: 10.1128/AEM.66.6.2385-2391.2000.
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Short report: possible Cryptosporidium muris infection in humans.简短报告：人类可能感染微小隐孢子虫
Am J Trop Med Hyg. 2000 Jan;62(1):70-2. doi: 10.4269/ajtmh.2000.62.70.
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Cryptosporidium andersoni n. sp. (Apicomplexa: Cryptosporiidae) from cattle, Bos taurus.来自家牛（Bos taurus）的安氏隐孢子虫（Cryptosporidium andersoni）新种（顶复门：隐孢子虫科）
J Eukaryot Microbiol. 2000 Jan-Feb;47(1):91-5. doi: 10.1111/j.1550-7408.2000.tb00016.x.
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Phylogenetic relationships among isolates of Cryptosporidium: evidence for several new species.隐孢子虫分离株之间的系统发育关系：几个新物种的证据。
J Parasitol. 1999 Dec;85(6):1126-33.
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Variation in Cryptosporidium: towards a taxonomic revision of the genus.隐孢子虫的变异：迈向该属的分类学修订
Int J Parasitol. 1999 Nov;29(11):1733-51. doi: 10.1016/s0020-7519(99)00109-5.
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The identification of Cryptosporidium species and Cryptosporidium parvum directly from whole faeces by analysis of a multiplex PCR of the 18S rRNA gene and by PCR/RFLP of the Cryptosporidium outer wall protein (COWP) gene.通过对18S rRNA基因进行多重PCR分析以及对隐孢子虫外壁蛋白（COWP）基因进行PCR/RFLP分析，直接从全粪便中鉴定隐孢子虫种类和微小隐孢子虫。
Int J Parasitol. 1999 Aug;29(8):1241-7. doi: 10.1016/s0020-7519(99)00079-x.
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Evaluation of Cryptosporidium parvum genotyping techniques.微小隐孢子虫基因分型技术评估
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10
Genetic characterization of Cryptosporidium strains from 218 patients with diarrhea diagnosed as having sporadic cryptosporidiosis.对218例被诊断为散发性隐孢子虫病的腹泻患者的隐孢子虫菌株进行基因特征分析。
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隐孢子虫寄生虫卵囊壁蛋白基因诊断靶区域的序列差异。

Sequence differences in the diagnostic target region of the oocyst wall protein gene of Cryptosporidium parasites.

作者信息

Xiao L, Limor J, Morgan U M, Sulaiman I M, Thompson R C, Lal A A

机构信息

National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341, USA.

出版信息

Appl Environ Microbiol. 2000 Dec;66(12):5499-502. doi: 10.1128/AEM.66.12.5499-5502.2000.

DOI:10.1128/AEM.66.12.5499-5502.2000
PMID:11097936
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC92490/
Abstract

Nucleotide sequences of the Cryptosporidium oocyst wall protein (COWP) gene were obtained from various Cryptosporidium spp. (C. wrairi, C. felis, C. meleagridis, C. baileyi, C. andersoni, C. muris, and C. serpentis) and C. parvum genotypes (human, bovine, monkey, marsupial, ferret, mouse, pig, and dog). Significant diversity was observed among species and genotypes in the primer and target regions of a popular diagnostic PCR. These results provide useful information for COWP-based molecular differentiation of Cryptosporidium spp. and genotypes.

摘要

隐孢子虫卵囊壁蛋白（COWP）基因的核苷酸序列取自多种隐孢子虫物种（怀氏隐孢子虫、猫隐孢子虫、火鸡隐孢子虫、贝利隐孢子虫、安氏隐孢子虫、鼠隐孢子虫和蛇隐孢子虫）以及微小隐孢子虫的不同基因型（人、牛、猴、有袋动物、雪貂、小鼠、猪和犬）。在一种常用诊断性聚合酶链反应（PCR）的引物和靶区域中，观察到不同物种和基因型之间存在显著差异。这些结果为基于COWP的隐孢子虫物种和基因型的分子鉴别提供了有用信息。