Ewert A, Folse D, Hillman G, Wang Y X
Am J Trop Med Hyg. 1983 Mar;32(2):385-91. doi: 10.4269/ajtmh.1983.32.385.
Cats with patent infections of Brugia malayi were treated by intraperitoneal injection of diethylcarbamazine citrate (DEC) for 6 consecutive days, weekly for 6 consecutive weeks or monthly for 3 months. Each cat received a total of 100 mg DEC per kg. At necropsy 7 months after infection, no living worms were recovered from any of eight cats treated weekly and only one of nine cats treated daily had a single living Brugia. Five of nine cats treated monthly and six of eight untreated controls had one or more living worms. Cats treated weekly showed a larger decline in microfilariae than those of the other treated groups. The mean microfilariae level of untreated controls increased 2-fold. At necropsy, gross appearance of regional lymphatics in daily and weekly treated cats resembled those of uninfected controls more closely than those in cats treated monthly or untreated. Differences in degree of histological changes between groups of infected cats were not apparent. Weekly administration of DEC appeared to be the most effective regimen; monthly treatment was less effective.
对感染马来布鲁线虫的猫，通过腹腔注射枸橼酸乙胺嗪（DEC）进行治疗，连续6天每天注射、连续6周每周注射或连续3个月每月注射。每只猫每千克体重共接受100毫克DEC。在感染后7个月进行尸检时，每周治疗的8只猫中没有一只检出活虫，每天治疗的9只猫中只有一只存在一条活的马来布鲁线虫。每月治疗的9只猫中有5只、8只未治疗的对照猫中有6只存在一条或多条活虫。每周治疗的猫体内微丝蚴数量的下降幅度大于其他治疗组。未治疗对照猫的平均微丝蚴水平增加了2倍。尸检时，每天和每周治疗的猫的局部淋巴管大体外观比每月治疗的猫或未治疗的猫更接近未感染对照猫。感染猫组之间组织学变化程度的差异不明显。每周给予DEC似乎是最有效的治疗方案；每月治疗效果较差。
