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与世界各地疫情相关的脑膜炎奈瑟菌ET-37复合体新变体的基因特征分析。

Genetic characterization of a new variant within the ET-37 complex of Neisseria meningitidis associated with outbreaks in various parts of the world.

作者信息

Jelfs J, Munro R, Ashto F E, Caugant D A

机构信息

Department of Microbiology and Infectious Diseases, South Western Area Pathology Service, Liverpool, NSW, Australia.

出版信息

Epidemiol Infect. 2000 Oct;125(2):285-98. doi: 10.1017/s0950268899004471.

DOI:10.1017/s0950268899004471
PMID:11117951
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2869600/
Abstract

A new variant within the electrophoretic type (ET)-37 complex of Neisseria meningitidis, ET-15, first detected in Canada in 1986, has been associated with severe clinical infections and high mortality rates in several European countries, Israel and Australia. To ascertain the genetic and epidemiological relationships of ET-15 strains from different geographical areas, 72 ET-15 isolates from 10 countries were compared to 13 isolates representing other clones of the ET-37 complex. The 85 strains were analysed by pulsed-field gel electrophoresis (PFGE) using 2 restriction endonucleases and Southern hybridization with 10 genetic markers. Four ET-15 strains and 4 other strains of the ET-37 complex were further examined using an additional restriction enzyme and a total of 18 genetic markers. PFGE fingerprints of the ET-15 strains were closely related. Strains within each country were even more closely related, suggesting single introductions of the clone. Physical mapping of genes in ET-15 and other strains of the ET-37 complex demonstrated that large genetic rearrangements of the genome have occurred in association with the appearance of the ET-15 variant.

摘要

1986年首次在加拿大检测到的脑膜炎奈瑟菌电泳型（ET）-37复合物中的一个新变种ET-15，在几个欧洲国家、以色列和澳大利亚与严重的临床感染及高死亡率相关。为确定来自不同地理区域的ET-15菌株的遗传和流行病学关系，将来自10个国家的72株ET-15分离株与代表ET-37复合物其他克隆的13株分离株进行了比较。使用2种限制性内切酶通过脉冲场凝胶电泳（PFGE）以及与10个遗传标记进行Southern杂交，对这85株菌株进行了分析。使用另外一种限制性内切酶和总共18个遗传标记，对4株ET-15菌株和4株ET-37复合物的其他菌株进行了进一步检测。ET-15菌株的PFGE指纹图谱密切相关。每个国家的菌株之间关系更为密切，表明该克隆为单次引入。对ET-15及ET-37复合物其他菌株中的基因进行物理图谱分析表明，基因组的大规模基因重排与ET-15变种的出现有关。