Al-Hashimi I, Khuder S, Haghighat N, Zipp M
Department of Periodontics, Baylor College of Dentistry, Dallas, TX 75246, USA.
J Oral Pathol Med. 2001 Jan;30(1):1-6. doi: 10.1034/j.1600-0714.2001.300101.x.
The purpose of this study was to examine the frequency and predictive value of glandular and extraglandular manifestations in S ogren's syndrome (SS). The clinical profiles of 169 SS patients were compared to those of 44 non-SS controls. The specific symptoms examined were oral, ocular, vaginal, gastric, pulmonary, skin, joint and muscle pain. Statistical analyses were performed on both individual and grouped symptoms. Chi-squared analyses showed that the frequency of all symptoms was significantly higher among patients than controls. Stepwise discriminant analysis of individual symptoms suggests that the combined symptoms of dry mouth, sore mouth, and dry eyes correctly classified 93% of SS and 97.7% of the controls. While grouped gastric, muscle, psychological, vaginal, skin, nasal, and thyroid symptoms correctly classified 64.3% of SS and 86.1% of the controls. This is the first study to examine the diagnostic value of multi-system manifestation in SS. The overall results suggest that a comprehensive questionnaire of various symptoms may assist the diagnosis of SS. The high predictive value of the combined symptoms confirms their value in the evaluation of SS.
本研究的目的是探讨干燥综合征（SS）中腺体及腺体外表现的频率和预测价值。将169例SS患者的临床资料与44例非SS对照者的临床资料进行比较。所检查的特定症状包括口腔、眼部、阴道、胃部、肺部、皮肤、关节和肌肉疼痛。对个体症状和分组症状均进行了统计分析。卡方分析显示，所有症状的出现频率在患者中显著高于对照组。对个体症状进行逐步判别分析表明，口干、口腔疼痛和干眼的联合症状能正确分类93%的SS患者和97.7%的对照者。而分组的胃部、肌肉、心理、阴道、皮肤、鼻部和甲状腺症状能正确分类64.3%的SS患者和86.1%的对照者。这是第一项研究SS多系统表现诊断价值的研究。总体结果表明，一份包含各种症状的综合问卷可能有助于SS的诊断。联合症状的高预测价值证实了它们在SS评估中的价值。
