Kan Y, Sakamoto B, Fujita T, Nagai H
Suntory Institute for Bioorganic Research, Wakayamadai, Shimamoto, Mishima-gun, Osaka 618-8503, Japan.
J Nat Prod. 2000 Dec;63(12):1599-602. doi: 10.1021/np000250t.
Isomalyngamides A and B (1, 2) were isolated and characterized from a collection of the cyanobacterium Lyngbya majuscula from Hawaiian waters. These compounds represent a new type of malyngamide, similar to malyngamides Q and R, in which the conformation of the chloromethylene group is opposite from the majority of previously reported malyngamides. The geometry of the chloromethylene moiety was elucidated from the long-range coupling constants ((3)J(C)(-)(H)) obtained from editing-HETLOC and phase-sensitive HMBC experiments. Isomalyngamides A and B (1, 2) showed lethal toxicity to crayfish.
异马琳酰胺A和B（1, 2）是从夏威夷海域采集的蓝藻巨大鞘丝藻中分离并鉴定出来的。这些化合物代表了一种新型的马琳酰胺，与马琳酰胺Q和R类似，其中亚甲基氯基团的构象与大多数先前报道的马琳酰胺相反。通过编辑-异核多量子相干（HETLOC）和相敏异核多键相关（HMBC）实验获得的远程耦合常数（3J(C)(-)(H)）阐明了亚甲基氯部分的几何结构。异马琳酰胺A和B（1, 2）对小龙虾显示出致命毒性。
