Côté E, Ettinger S J
California Animal Hospital, Los Angeles, USA.
J Vet Intern Med. 2001 Jan-Feb;15(1):39-42. doi: 10.1892/0891-6640(2001)015<0039:lcmorp>2.3.co;2.
A small number of dogs with patent ductus arteriosus (PDA) have right-to-left flow of blood through the ductus, leading to polycythemia and clinical signs associated with hyperviscosity. Three dogs with right-to-left-shunting PDA are described. Treatment consisted solely of phlebotomy, performed on an outpatient basis when indicated by exacerbation of clinical signs, for a total of 11-68 times on each dog. Each treatment entailed the removal of a mean of 19% (maximum 28%) of circulating blood volume, divided into 2 phlebotomies several hours apart, without intravenous fluid replacement. Subjectively, marked clinical improvement was noted. Intermittent clinical signs decreased in frequency and severity in all dogs. Adverse effects were rare (1 for 98 phlebotomies) and reversible. Dogs lived > 2 to > 8 years during treatment. Outpatient phlebotomy without fluid replacement was safe, and was associated with subjective improvement and prolonged survival in these dogs.
少数患有动脉导管未闭（PDA）的犬只存在血液通过动脉导管从右向左分流的情况，导致红细胞增多症以及与血液高黏滞度相关的临床症状。本文描述了3只存在右向左分流型PDA的犬只。治疗仅采用放血疗法，在临床症状加重时进行门诊放血，每只犬共放血11 - 68次。每次治疗平均抽取循环血容量的19%（最多28%），分两次在数小时内进行，不放静脉补液。主观上，观察到临床症状有显著改善。所有犬只间歇性临床症状的频率和严重程度均有所降低。不良反应罕见（98次放血中有1次）且可逆转。治疗期间犬只存活时间超过2至8年。门诊不放液的放血疗法是安全的，且与这些犬只主观症状的改善及生存期延长相关。
