兴奋性突触输入的树突整合

Dendritic integration of excitatory synaptic input.

作者信息

Magee J C

机构信息

Neuroscience Center, Louisiana State University Medical Center, 2,020 Gravier Street, New Orleans, Louisiana 70112, USA. jmageelsumc.edu

出版信息

Nat Rev Neurosci. 2000 Dec;1(3):181-90. doi: 10.1038/35044552.

DOI:10.1038/35044552

PMID:11257906

Abstract

A fundamental function of nerve cells is the transformation of incoming synaptic information into specific patterns of action potential output. An important component of this transformation is synaptic integration--the combination of voltage deflections produced by a myriad of synaptic inputs into a singular change in membrane potential. There are three basic elements involved in integration: the amplitude of the unitary postsynaptic potential; the manner in which non-simultaneous unitary events add in time (temporal summation), and the addition of unitary events occurring simultaneously in separate regions of the dendritic arbor (spatial summation). This review discusses how passive and active dendritic properties, and the functional characteristics of the synapse, shape these three elements of synaptic integration.

摘要

神经细胞的一项基本功能是将传入的突触信息转化为特定模式的动作电位输出。这种转化的一个重要组成部分是突触整合——将无数突触输入产生的电压偏转组合成膜电位的单一变化。整合涉及三个基本要素：单突触后电位的幅度；非同时发生的单突触事件在时间上相加的方式（时间总和），以及在树突分支的不同区域同时发生的单突触事件的相加（空间总和）。本综述讨论了被动和主动的树突特性以及突触的功能特征如何塑造突触整合的这三个要素。