多形核白细胞对细胞膜氧化脂质成分的趋化作用。
Polymorphonulcear leukocyte chemotaxis toward oxidized lipid components of cell membranes.
作者信息
Turner S R, Campbell J A, Lynn W S
出版信息
J Exp Med. 1975 Jun 1;141(6):1437-41. doi: 10.1084/jem.141.6.1437.
Abstract
Polymorphonuclear leukocyte chemotaxis has been elicited by oxidized arachidonic acid and other oxidized polyenoic lipids in the Boyden micropore filter assay system. This chemotactic activity was observed in the absence of serum and chemotactic proteins. The esterfied arachidonic acid present in plasma membranes may be a precursor of chemotactic messages as well as prostaglandins in vivo.
摘要
在博伊登微孔滤膜分析系统中，氧化型花生四烯酸和其他氧化型多烯脂质可引发多形核白细胞趋化作用。在无血清和趋化蛋白的情况下可观察到这种趋化活性。质膜中存在的酯化花生四烯酸在体内可能既是趋化信息的前体，也是前列腺素的前体。
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