Setiawan V W, Zhang Z F, Yu G P, Lu Q Y, Li Y L, Lu M L, Wang M R, Guo C H, Yu S Z, Kurtz R C, Hsieh C C
Department of Epidemiology, UCLA School of Public Health, and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095-1772, USA.
Int J Cancer. 2001 May 15;92(4):600-4. doi: 10.1002/ijc.1231.
Despite the declining trend, stomach cancer remains the second most common cancer worldwide. We examined the role of green tea consumption on chronic gastritis and stomach cancer risks. A population-based case-control study was conducted in Yangzhong, China, with 133 stomach cancer cases, 166 chronic gastritis cases, and 433 healthy controls. Epidemiologic data were collected by standard questionnaire and odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models in SAS. Inverse association was observed between green tea drinking and chronic gastritis and stomach cancer risks. After adjusting for age, gender, education, body mass index, pack-years of smoking and alcohol drinking, ORs of green tea drinking were 0.52 (95% CI: 0.29-0.94) and 0.49 (95% CI: 0.31-0.77) for stomach cancer and chronic gastritis, respectively. In addition, dose-response relationships were observed with years of green tea drinking in both diseases. The results provide further support on the protective effect of green tea against stomach cancer. This is the first time that green tea drinking was found to be protective against chronic gastritis, which may be of importance when designing intervention strategies for stomach cancer and its pre-malignant lesions in the high-risk population.
尽管呈下降趋势，但胃癌仍是全球第二大常见癌症。我们研究了饮用绿茶对慢性胃炎和胃癌风险的作用。在中国扬中进行了一项基于人群的病例对照研究，有133例胃癌病例、166例慢性胃炎病例和433名健康对照者。通过标准问卷收集流行病学数据，并在SAS中使用逻辑回归模型估计比值比（OR）和95%置信区间（CI）。观察到饮用绿茶与慢性胃炎和胃癌风险之间存在负相关。在调整年龄、性别、教育程度、体重指数、吸烟包年数和饮酒量后，饮用绿茶对胃癌和慢性胃炎的OR分别为0.52（95%CI：0.29 - 0.94）和0.49（95%CI：0.31 - 0.77）。此外，在这两种疾病中均观察到饮用绿茶年限与剂量反应关系。这些结果进一步支持了绿茶对胃癌的保护作用。这是首次发现饮用绿茶对慢性胃炎有保护作用，这在为高危人群设计胃癌及其癌前病变的干预策略时可能具有重要意义。
