一项关于日本胃癌与绿茶消费关系的巢式病例对照研究。
A nested case-control study of stomach cancer in relation to green tea consumption in Japan.
作者信息
Hoshiyama Y, Kawaguchi T, Miura Y, Mizoue T, Tokui N, Yatsuya H, Sakata K, Kondo T, Kikuchi S, Toyoshima H, Hayakawa N, Tamakoshi A, Ohno Y, Yoshimura T
机构信息
Department of Public Health, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa, Tokyo 142-8555, Japan.
出版信息
Br J Cancer. 2004 Jan 12;90(1):135-8. doi: 10.1038/sj.bjc.6601512.
To evaluate whether green tea consumption provides protection against stomach cancer, the relative risks (RRs) were calculated in the Japan Collaborative Study for Evaluation of Cancer Risk, sponsored by the Ministry of Health and Welfare (JACC Study). The study was based on 157 incident cases and 285 controls aged 40-79 years. Cox proportional hazards regression analysis was used to estimate the RRs for stomach cancer. It was found that green tea consumption had no protective effect against stomach cancer. After adjustment for age, smoking status, H. pylori infection, history of peptic ulcer, and family history of stomach cancer along with certain dietary elements, the risks associated with drinking one or two, three or four, five to nine, and 10 or more cups of green tea per day, relative to those of drinking less than one cup per day, were 1.3 (95% confidence interval (CI): 0.6-2.8), 1.0 (95% CI: 0.5-1.9), 0.8 (95% CI: 0.4-1.6), and 1.2 (95% CI: 0.6-2.5), respectively (P for trend=0.899). We found no inverse association between green tea consumption and the risk of stomach cancer.
为评估饮用绿茶是否能预防胃癌，在厚生省资助的日本癌症风险评估协作研究（JACC研究）中计算了相对风险（RRs）。该研究基于157例新发病例和285名年龄在40 - 79岁的对照。采用Cox比例风险回归分析来估计胃癌的RRs。结果发现饮用绿茶对胃癌没有保护作用。在对年龄、吸烟状况、幽门螺杆菌感染、消化性溃疡病史、胃癌家族史以及某些饮食因素进行调整后，与每天饮用少于一杯绿茶相比，每天饮用一或两杯、三或四杯、五至九杯以及10杯或更多杯绿茶的相关风险分别为1.3（95%置信区间（CI）：0.6 - 2.8）、1.0（95%CI：0.5 - 1.9）、0.8（95%CI：0.4 - 1.6）和1.2（95%CI：0.6 - 2.5）（趋势P值 = 0.899）。我们未发现饮用绿茶与胃癌风险之间存在负相关。
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