土耳其脊髓损伤患者冠心病的危险因素。

Risk factors for coronary heart disease in patients with spinal cord injury in Turkey.

作者信息

Demirel S, Demirel G, Tükek T, Erk O, Yilmaz H

机构信息

Cardiovascular Diseases Research Centre, Istanbul University Medical Faculty, Istanbul, Turkey.

出版信息

Spinal Cord. 2001 Mar;39(3):134-8. doi: 10.1038/sj.sc.3101135.

DOI:10.1038/sj.sc.3101135

PMID:11326322

Abstract

OBJECTIVE

To compare the standard risk factors for coronary heart disease (CHD), defined in National Cholesterol Education Program II (NCEP II) of Turkish spinal cord injury (SCI) patients with healthy controls, discuss the results according to the findings in Turkish population, and SCI patients in the literature.

DESIGN

We assessed 52 age and sex matched healthy control subjects, and 69 SCI patients (16 females, 53 males with the mean age of 33.9+/-11.37 years) with time since injury of 12.8+/-13.45 months. The study consisted of 45 paraplegics, and 24 tetraplegics with 54% incomplete, and 46% complete injury.

RESULTS

Risk factors for CHD according to NCEP II were; age and sex in 16%, positive family history in 0%, cigarette smoking in 54%, hypertension (HT) in 0%, high total cholesterol (TC) in 32%, high low-density lipoprotein cholesterol (LDL) in 41%, low high-density lipoprotein cholesterol (HDL) in 52%, and diabetes mellitus (DM) in 7% of our SCI patients, respectively. Compared to controls DM, high TC, LDL, and low HDL were statistically more frequent in SCI patients. We found a negative correlation between serum HDL and time since injury. TC (186+/-32 vs 205+/-36; P=0.025), TC/HDL (5.34+/-1.17 vs 6.26+/-1.5; P=0.005), and LDL/HDL (3.57+/-0.9 vs 4.16+/-1.3; P=0.027) were significantly increased in patients with time since injury of more than 1 year, while HDL levels (35.8+/-6.36 vs 33.86+/-6.47; P=0.213) decreased without reaching statistical significance. The lipid profiles did not show any correlation with the neurological level, and completeness of lesions.

CONCLUSIONS

SCI confers additional CHD risk over that present inherently in the parent population due to enforced sedentary lifestyle and this increases with time since injury. The preliminary study consisting of 26 patients was accepted for poster presentation in Copenhagen, Denmark (18-20 June 1999) at the 38th Annual Scientific Meeting of IMSOP in association with the Nordic Medical Society of Paraplegia.

摘要

目的

比较土耳其脊髓损伤（SCI）患者的冠心病（CHD）标准风险因素与健康对照，根据土耳其人群和文献中SCI患者的研究结果讨论这些结果。

设计

我们评估了52名年龄和性别匹配的健康对照者，以及69名SCI患者（16名女性，53名男性，平均年龄33.9±11.37岁），受伤时间为12.8±13.45个月。该研究包括45名截瘫患者和24名四肢瘫患者，其中54%为不完全损伤，46%为完全损伤。

结果

根据美国国家胆固醇教育计划II（NCEP II），我们的SCI患者中冠心病的风险因素分别为：年龄和性别占16%，家族史阳性占0%，吸烟占54%，高血压（HT）占0%，总胆固醇（TC）高占32%，低密度脂蛋白胆固醇（LDL）高占41%，高密度脂蛋白胆固醇（HDL）低占52%，糖尿病（DM）占7%。与对照组相比，SCI患者中DM、高TC、LDL和低HDL在统计学上更为常见。我们发现血清HDL与受伤时间呈负相关。受伤时间超过1年的患者中，TC（186±32 vs 205±36；P=0.025）、TC/HDL（5.34±1.17 vs 6.26±1.5；P=0.005）和LDL/HDL（3.57±0.9 vs 4.16±1.3；P=0.