Kwok Y Y, Tally F P, Sutter V L, Finegold S M
Antimicrob Agents Chemother. 1975 Jan;7(1):1-7. doi: 10.1128/AAC.7.1.1.
The susceptibility of 55 strains of slow-growing anaerobes to eight clinically useful or potentially useful antibiotics was determined by agar dilution and disk diffusion tests. Strains of the genera Peptococcus, Peptostreptococcus, Megasphaera, Veillonella, Eubacterium, Bifidobacterium, Clostridium, and Fusobacterium were included. All strains were susceptible to chloramphenicol, but varied in their susceptibility to penicillin, lincomycin, clindamycin, tetracyclines, and vancomycin. Correlation between minimal inhibitory concentration and inhibition zone diameters was generally good. Prediction of susceptibility based on zone diameter measurements appeared satisfactory. Although routine susceptibility testing of anaerobic bacteria is not recommended, there are circumstances where such testing is relevant to the clinical situation. For those laboratories ill-equipped to do dilution tests, a disk diffusion test would give relatively accurate preliminary information. Quantitative susceptibility tests could then be done by a reference laboratory.
通过琼脂稀释法和纸片扩散试验测定了55株生长缓慢的厌氧菌对8种临床常用或可能有用的抗生素的敏感性。其中包括消化球菌属、消化链球菌属、巨球形菌属、韦荣球菌属、真杆菌属、双歧杆菌属、梭菌属和梭杆菌属的菌株。所有菌株对氯霉素均敏感，但对青霉素、林可霉素、克林霉素、四环素和万古霉素的敏感性各不相同。最低抑菌浓度与抑菌圈直径之间的相关性总体良好。基于抑菌圈直径测量预测敏感性似乎是令人满意的。虽然不建议对厌氧菌进行常规药敏试验，但在某些情况下，这种试验与临床情况相关。对于那些没有能力进行稀释试验的实验室，纸片扩散试验可以提供相对准确的初步信息。然后可由参考实验室进行定量药敏试验。
