Sapico F L, Kwok Y Y, Sutter V L, Finegold S M
Antimicrob Agents Chemother. 1972 Oct;2(4):320-5. doi: 10.1128/AAC.2.4.320.
The in vitro susceptibility of 43 strains of Clostridium perfringens to nine antibiotics was determined by a standardized test for rapid-growing anaerobes. Good correlation was established between the agar dilution susceptibility and the disc diffusion susceptibility results. The inhibition zone diameters around the antibiotic discs, however, were generally much smaller than those of gram-negative anaerobes previously studied. All of the strains tested were susceptible in vitro to chloramphenicol, clindamycin, doxycycline, minocycline, penicillin, and vancomycin. Erythromycin showed poor in vitro activity against this organism, with only 7% of the strains susceptible, 72% intermediate in susceptibility, and 21% resistant. In tests of the 43 strains against lincomycin, 58% were susceptible, 32.5% were intermediate in susceptibility, and 9.5% were resistant. Against tetracycline, 37% of the strains were intermediate in susceptibility and the rest were susceptible.
通过一种针对快速生长厌氧菌的标准化试验，测定了43株产气荚膜梭菌对9种抗生素的体外敏感性。琼脂稀释法药敏试验结果与纸片扩散法药敏试验结果之间具有良好的相关性。然而，抗生素纸片周围的抑菌圈直径通常比先前研究的革兰氏阴性厌氧菌的抑菌圈直径小得多。所有测试菌株在体外对氯霉素、克林霉素、强力霉素、米诺环素、青霉素和万古霉素敏感。红霉素对该菌的体外活性较差，只有7%的菌株敏感，72%的菌株中度敏感，21%的菌株耐药。在对43株菌株进行林可霉素测试时，58%的菌株敏感，32.5%的菌株中度敏感，9.5%的菌株耐药。对于四环素，37%的菌株中度敏感，其余菌株敏感。
