Mosley C, Whittle C, Hicks C
Special Care Baby Unit, Macclesfield District General Hospital, UK.
Midwifery. 2001 Jun;17(2):150-7. doi: 10.1054/midw.2000.0244.
to compare the impact of two methods of supplementary feeding of pre-term babies (bottle vs cup) on subsequent breast feeding and to assess the feasibility of using a randomised controlled trial (RCT) to investigate the topic.
small scale prospective RCT. Data on breast feeding, as defined as the exclusive method of feeding, were collected. A range of relevant bio-data was also collected and their impact on breast feeding assessed.
a special care baby unit in a District General Hospital in the UK.
over a three-month period, all pre-term babies (32-37 weeks' gestation) who fulfilled the inclusion criteria and has been born to mothers who had expressed a pre-partum desire to breast feed, who had consented to take part, were included (n=14).
the eligible babies were randomly allocated to supplementary feeding of breast milk, via either a cup or a bottle. Whether or not the baby was being breast fed at discharge was noted.
the study suggested that this RCT framework is a viable method of investigating baby feeding. Because of the small-scale nature of the project, the actual database must be treated with extreme caution. No significant differences were found between the two groups in terms of breast feeding. However, the mothers reported high levels of support and also the breast-feeding rates were above the national averages. These two findings could have contributed to the non-significant results observed in this analysis.
if the present findings could be supported by further research, then the non-significant results relating method of supplementary feeds to subsequent breast feeding could be explained by reference to three factors. Firstly, there is, in fact, no real effect of method of supplementary feeding and subsequent breast feeding; secondly, the method adopted differed from existing research and thus may be expected to produce non-corroborative results; and finally, the overall levels of breast feeding within the Unit generally were higher than the national average. The relevance of the RCT for investigating this subject is also discussed with reference to the present data set. Further experimental work to develop these ideas and to identify causal links is required.
比较两种给早产儿补充喂养的方法（奶瓶喂养与杯喂）对后续母乳喂养的影响，并评估采用随机对照试验（RCT）来研究该主题的可行性。
小规模前瞻性随机对照试验。收集了关于母乳喂养的数据，母乳喂养被定义为唯一的喂养方式。还收集了一系列相关的生物数据，并评估了它们对母乳喂养的影响。
英国一家地区综合医院的特殊护理婴儿病房。
在三个月的时间里，纳入了所有符合纳入标准、母亲在产前表示有母乳喂养意愿且已同意参与的早产儿（妊娠32 - 37周）（n = 14）。
符合条件的婴儿被随机分配通过杯子或奶瓶进行母乳补充喂养。记录婴儿出院时是否正在进行母乳喂养。
该研究表明，这个随机对照试验框架是研究婴儿喂养的一种可行方法。由于项目规模较小，实际数据库必须极其谨慎对待。两组在母乳喂养方面未发现显著差异。然而，母亲们报告得到了高水平的支持，而且母乳喂养率高于全国平均水平。这两个发现可能导致了本分析中观察到的无显著差异结果。
如果目前的研究结果能得到进一步研究的支持，那么补充喂养方式与后续母乳喂养之间无显著差异的结果可以通过三个因素来解释。首先，实际上补充喂养方式对后续母乳喂养没有真正影响；其次，采用的方法与现有研究不同，因此可能会产生无法确证的结果；最后，该病房内母乳喂养的总体水平普遍高于全国平均水平。还参照当前数据集讨论了随机对照试验对研究该主题的相关性。需要进一步开展实验工作来拓展这些观点并确定因果关系。
