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Pentalenolactone I and hygromycin A, immunosuppressants produced by Streptomyces filipinensis and Streptomyces hygroscopicus.

作者信息

Uyeda M, Mizukami M, Yokomizo K, Suzuki K

机构信息

Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.

出版信息

Biosci Biotechnol Biochem. 2001 May;65(5):1252-4. doi: 10.1271/bbb.65.1252.

DOI:10.1271/bbb.65.1252
PMID:11440152
Abstract

Immunosuppressants isolated from Streptomyces filipinensis and S. hygroscopicus were identified with pentalenolactone I and hygromycin A, respectively. The compounds as well as cyclosporin A showed immunosuppressant activity in the mixed lymphocyte reaction, and pentalenolactone I and cyclosporin A suppressed IL-2 production, however, hygromycin A did not. Hygromycin A may have immunosuppressant activity by a different mechanism from pentalenolactone I, cyclosporin A and tacrolimus.

摘要

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