通过气溶胶、鼻腔、结膜、胃和皮下途径使豚鼠暴露于立氏立克次氏体，并观察一种实验性疫苗提供的保护作用。
Exposure of guinea pigs to Rickettsia rickettsii by aerosol, nasal, conjunctival, gastric, and subcutaneous routes and protection afforded by an experimental vaccine.
作者信息
Kenyon R H, Kishimoto R A, Hall W C
出版信息
Infect Immun. 1979 Aug;25(2):580-2. doi: 10.1128/iai.25.2.580-582.1979.
Abstract
Guinea pigs were inoculated with Rocky Mountain spotted fever by the aerosol, conjunctival, subcutaneous, intragastric, and intranasal routes. Rickettsial infection was produced by all routes except intragastric. All animals with clinical signs of disease developed agglutinating antibody, and most developed a cell-mediated immune response. Disease produced by all experimental routes (except intragastric) was indistinguishable. The tissue culture-derived inactivated vaccine produced in this laboratory protected guinea pigs against an aerosol challenge.
摘要
通过气溶胶、结膜、皮下、胃内和鼻内途径给豚鼠接种落基山斑疹热。除胃内途径外，所有途径均能引发立克次体感染。所有出现疾病临床症状的动物都产生了凝集抗体，且大多数产生了细胞介导的免疫反应。所有实验途径（除胃内途径外）引发的疾病并无差异。本实验室生产的组织培养衍生灭活疫苗可保护豚鼠免受气溶胶攻击。
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