Yoshimura T, Kaneko S, Hayabuchi H
Department of Clinical Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka Yahatanishi-ku, Kitakyushu, 807-8555, Japan.
Occup Environ Med. 2001 Aug;58(8):540-1. doi: 10.1136/oem.58.8.540.
Sex ratios in the offspring of those affected by dioxins or dioxin-like compounds have been reported from Seveso, Italy and Yucheng, Taiwan. The sex ratio of live births in Yusho, Japan after a similar accidental massive exposure to polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) in 1968 are reviewed. Data on all births among parents exposed to the compounds from 1968 to 1977 in Fukuoka and a region of Nagasaki, the two areas affected, are reported. In total there were 85 live births in those regions. The sex ratio was not significantly different from normal (0.513). To evaluate hormonal disrupting activity or effects on reproductive outcome by PCBs and PCDFs, a further investigation of sex in offspring of the Yusho victims, especially offspring of those who were younger than 19 years of age at the time of the Yusho incident, is needed.
意大利塞韦索和中国台湾地区的玉井曾报告过受二噁英或类二噁英化合物影响人群后代的性别比例。本文回顾了1968年日本油症事件中,在类似的意外大规模接触多氯联苯(PCBs)和多氯二苯并呋喃(PCDFs)后活产婴儿的性别比例。报告了1968年至1977年期间,受影响的福冈和长崎部分地区中,接触这些化合物的父母所生育的所有婴儿的数据。这些地区共有85例活产。性别比例与正常情况无显著差异(0.513)。为评估多氯联苯和多氯二苯并呋喃对激素的干扰活性或对生殖结果的影响,需要对油症受害者的后代,尤其是在油症事件发生时年龄小于19岁者的后代性别进行进一步调查。