Ryan J J, Gasiewicz T A, Brown J F
Food Research Division, Health and Welfare Canada, Ottawa, Ontario.
Fundam Appl Toxicol. 1990 Nov;15(4):722-31. doi: 10.1016/0272-0590(90)90188-p.
The polychlorinated dibenzofurans (PCDFs) are one group of man-made toxicants for which reasonably extensive data exist relevant to dose-response relationships in humans. Examination of contaminated food oil consumption from the yusho (Japan) poisoning incident indicates the mean uptake or body burden of 2, 3, 4, 7, 8-pentachlorodibenzofuran (PnCDF) equivalents (PEQ) associated with nausea and anorexia to be 4.4 micrograms/kg body wt and that associated with chloracne to be 5.9 micrograms/kg. For the yucheng (Taiwan) poisoning incident, blood measurements for chloracne show a similar body burden of 4.0 micrograms/kg. The latter value is toxicologically equivalent to a 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalent (TEQ) body burden of 2.0 micrograms/kg body wt or about 150 micrograms for an adult person. This corresponds to an adipose tissue level of about 10 micrograms/kg fat, and is comparable to that known to cause chloracne in rhesus monkeys. These body burdens on a TEQ basis are more than 200 times higher than the average current levels of PCDDs/PCDFs found in North American populations and are the first to relate human body burdens of PCDFs with a known effect and to compare them to animal data. Since the effects reported may not be the most sensitive indicator of human toxicity, lower body burdens could be associated with more subtle toxicological events.
多氯二苯并呋喃（PCDFs）是一类人造毒物，目前已有相当广泛的数据涉及人类的剂量反应关系。对日本“油症”中毒事件中受污染食用油摄入量的调查表明，与恶心和厌食相关的2,3,4,7,8 - 五氯二苯并呋喃（PnCDF）当量（PEQ）的平均摄入量或体内负荷为4.4微克/千克体重，与氯痤疮相关的为5.9微克/千克。对于台湾“油症”中毒事件，氯痤疮患者的血液检测显示体内负荷相似，为4.0微克/千克。后一数值在毒理学上相当于2,3,7,8 - 四氯二苯并对二恶英当量（TEQ）体内负荷2.0微克/千克体重，对于成年人约为150微克。这相当于脂肪组织中约10微克/千克脂肪的水平，与已知在恒河猴中引起氯痤疮的水平相当。基于TEQ的这些体内负荷比北美人群中目前发现的PCDDs/PCDFs平均水平高出200多倍，并且首次将人体PCDFs的体内负荷与已知效应联系起来，并与动物数据进行比较。由于所报告的效应可能不是人类毒性的最敏感指标，较低的体内负荷可能与更细微的毒理学事件相关。
