Jobe J B, Smith D M, Ball K, Tennstedt S L, Marsiske M, Willis S L, Rebok G W, Morris J N, Helmers K F, Leveck M D, Kleinman K
Behavioral and Social Research Program, National Institute on Aging, Bethesda, MD, USA.
Control Clin Trials. 2001 Aug;22(4):453-79. doi: 10.1016/s0197-2456(01)00139-8.
The Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) trial is a randomized, controlled, single-masked trial designed to determine whether cognitive training interventions (memory, reasoning, and speed of information processing), which have previously been found to be successful at improving mental abilities under laboratory or small-scale field conditions, can affect cognitively based measures of daily functioning. Enrollment began during 1998; 2-year follow-up will be completed by January 2002. Primary outcomes focus on measures of cognitively demanding everyday functioning, including financial management, food preparation, medication use, and driving. Secondary outcomes include health-related quality of life, mobility, and health-service utilization. Trial participants (n = 2832) are aged 65 and over, and at entry into the trial, did not have significant cognitive, physical, or functional decline. Because of its size and the carefully developed rigor, ACTIVE may serve as a guide for future behavioral medicine trials of this nature.
“老年人独立和活力的高级认知训练”（ACTIVE）试验是一项随机、对照、单盲试验，旨在确定认知训练干预措施（记忆力、推理能力和信息处理速度）能否影响基于认知的日常功能指标。此前在实验室或小规模现场条件下，这些干预措施已被证明能成功提高心理能力。招募工作于1998年开始；2年随访将于2002年1月完成。主要结果集中在对认知要求较高的日常功能指标上，包括财务管理、食物准备、药物使用和驾驶。次要结果包括与健康相关的生活质量、行动能力和医疗服务利用情况。试验参与者（n = 2832）年龄在65岁及以上，进入试验时没有明显的认知、身体或功能衰退。由于其规模和精心制定的严谨性，ACTIVE试验可作为此类未来行为医学试验的指南。
