Monteiro I M, Boksay I, Auer S R, Torossian C, Ferris S H, Reisberg B
Aging and Dementia Research Center, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Eur Psychiatry. 2001 Jan;16 Suppl 1:5s-24s. doi: 10.1016/s0924-9338(00)00524-1.
The Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD) is a well-established instrument, designed to assess potentially remediable behavioral symptoms in Alzheimer's disease (AD) patients as well as to evaluate treatment outcome. It consists of 25 symptoms grouped into seven categories. Each symptom is scored on the basis of severity on a four-point scale. A knowledgeable caregiver is queried and items are scored on the basis of symptoms noted in the preceding two weeks. Reliability, construct validity and criterion validity data for the BEHAVE-AD have previously been published. Because of the significance of psychopathology in dementia, it is necessary to optimally describe and define the nature, magnitude and prevalence of behavioral symptomatology. Accordingly, a frequency component was added to each of the 25 items of the BEHAVE-AD scale. The objective of the present report is to describe this new Behavioral Pathology in Alzheimer's Disease Frequency-Weighted Severity Scale (BEHAVE-AD-FW) and to establish its inter-rater reliability. In this investigation the BEHAVE-AD-FW scale was administered to caregivers of 28 patients with either mildly impaired cognitive function or a dementia diagnosis. Two clinicians separately and independently rated the responses. Analyses determined that the intraclass correlation coefficients (ICCs) for the frequency component varied between 0.86 and 0.97 for each of the seven BEHAVE-AD categories (p(s) < 0.001). ICCs for the frequency-weighted scores (item severity score x item frequency score) ranged from 0.69 to 0.98 for the seven symptom categories (p(s) < 0.001). For the BEHAVE-AD-FW total scores, the ICC was 0.91 (P < 0.001). These results indicate that the frequency-weighted component is a reliable addition to the BEHAVE-AD scale.
阿尔茨海默病行为病理学评定量表（BEHAVE-AD）是一种成熟的工具，旨在评估阿尔茨海默病（AD）患者潜在可矫正的行为症状，并评估治疗效果。它由25种症状组成，分为七类。每种症状根据严重程度在四点量表上评分。询问一位知识渊博的照料者，并根据前两周观察到的症状对条目进行评分。BEHAVE-AD的信度、结构效度和效标效度数据此前已发表。由于精神病理学在痴呆症中的重要性，有必要对行为症状学的性质、程度和患病率进行最佳描述和界定。因此，在BEHAVE-AD量表的25个条目中，每个条目都增加了一个频率成分。本报告的目的是描述这种新的阿尔茨海默病频率加权严重程度量表（BEHAVE-AD-FW），并确定其评分者间信度。在这项研究中，BEHAVE-AD-FW量表应用于28例认知功能轻度受损或诊断为痴呆症患者的照料者。两名临床医生分别独立对回答进行评分。分析确定，七个BEHAVE-AD类别中每个类别的频率成分的组内相关系数（ICC）在0.86至0.97之间（p值<0.001）。七个症状类别的频率加权分数（条目严重程度分数×条目频率分数）的ICC范围为0.69至0.98（p值<0.001）。对于BEHAVE-AD-FW总分，ICC为0.91（P<0.001）。这些结果表明，频率加权成分是BEHAVE-AD量表可靠的补充。
