Dockery D W
Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Environ Health Perspect. 2001 Aug;109 Suppl 4(Suppl 4):483-6. doi: 10.1289/ehp.01109s4483.
In the past decade researchers have developed a body of epidemiologic evidence showing increased daily cardiovascular mortality and morbidity associated with acute exposures to particulate air pollution. Associations have been found not only with cardiovascular deaths reported on death certificates but also with myocardial infarctions and ventricular fibrillation. Particulate air pollution exposure has been associated with indicators of autonomic function of the heart including increased heart rate, decreased heart rate variability, and increased cardiac arrhythmias. Several markers of increased risk for sudden cardiac death have also been associated with such exposures. These epidemiologic studies provide early guidance to possible pathways of particulate air pollution health effects, which can only be addressed fully in toxicologic and physiologic studies.
在过去十年中，研究人员已积累了大量流行病学证据，表明急性暴露于空气中的颗粒物会使心血管疾病的每日死亡率和发病率上升。不仅发现其与死亡证明上报告的心血管死亡有关，还与心肌梗死和心室颤动有关。暴露于空气中的颗粒物已与心脏自主功能指标相关，包括心率加快、心率变异性降低和心律失常增加。心脏性猝死风险增加的几个标志物也与这种暴露有关。这些流行病学研究为颗粒物空气污染对健康产生影响的可能途径提供了早期指导，而这只有在毒理学和生理学研究中才能得到充分探讨。
