Hallgren C G, Hallmans G, Jansson J H, Marklund S L, Huhtasaari F, Schütz A, Strömberg U, Vessby B, Skerfving S
Unit for Community Medicine, County Council of Västerbotten, 901 85 Umeå, Sweden.
Br J Nutr. 2001 Sep;86(3):397-404. doi: 10.1079/bjn2001415.
High intake of fish has been associated with reduced risk of CHD. The high content of n-3 polyunsaturated fatty acids (PUFA) in fish has been suggested to be a protective factor. In addition, fish is the entirely dominating source of methylmercury for the general population, and the concentration of Hg in erythrocytes (Ery-Hg) is often used as an index of fish consumption. Our aim was to study the relationships between a first-ever myocardial infarction, Ery-Hg, activity of gluthathione peroxidase in erythrocytes (Ery-GSH-Px) and plasma concentration of the n-3 PUFA eicosapentaenoic and docosahexaenoic acids (P-PUFA). In a population-based prospective nested case-control study within Northern Sweden seventy-eight cases of a first-ever myocardial infarction were compared with 156 controls with respect to Ery-Hg, P-PUFA and Ery-GSH-Px. Both Ery-Hg and P-PUFA, but not Ery-GSH-Px, were significantly higher in subjects reporting high fish intake (at least one meal per week) than in those with lower intake. This finding suggests that Ery-Hg and P-PUFA reflect previous long-term fish intake. Low risk of myocardial infarction was associated with high Ery-Hg or high P-PUFA. In a multivariate model the risk of myocardial infarction was further reduced in subjects with both high Ery-Hg and high P-PUFA (odds ratio 0.16, 95 % CI 0.04, 0.65). In conclusion, there is a strong inverse association between the risk of a first myocardial infarction and the biomarkers of fish intake, Ery-Hg and P-PUFA, and this association is independent of traditional risk factors.
鱼类摄入量高与冠心病风险降低有关。鱼类中n-3多不饱和脂肪酸（PUFA）含量高被认为是一个保护因素。此外，鱼类是普通人群甲基汞的主要来源，红细胞中汞的浓度（Ery-Hg）常被用作鱼类消费量的指标。我们的目的是研究首次心肌梗死、Ery-Hg、红细胞谷胱甘肽过氧化物酶活性（Ery-GSH-Px）与n-3多不饱和脂肪酸二十碳五烯酸和二十二碳六烯酸的血浆浓度（P-PUFA）之间的关系。在瑞典北部一项基于人群的前瞻性巢式病例对照研究中，比较了78例首次心肌梗死病例与156例对照在Ery-Hg、P-PUFA和Ery-GSH-Px方面的情况。报告鱼类摄入量高（每周至少一餐）的受试者的Ery-Hg和P-PUFA均显著高于摄入量较低的受试者，但Ery-GSH-Px并非如此。这一发现表明Ery-Hg和P-PUFA反映了既往长期的鱼类摄入量。心肌梗死低风险与高Ery-Hg或高P-PUFA相关。在多变量模型中，Ery-Hg和P-PUFA均高的受试者心肌梗死风险进一步降低（优势比0.16，95%可信区间0.04，0.65）。总之，首次心肌梗死风险与鱼类摄入量的生物标志物Ery-Hg和P-PUFA之间存在强烈的负相关，且这种关联独立于传统风险因素。
