Acanthopanax senticosus root inhibits mast cell-dependent anaphylaxis.

作者信息

Yi J M, Kim M S, Seo S W, Lee K N, Yook C S, Kim H M

机构信息

Department of Oriental Pharmacy, College of Pharmacy and Center of Oriental Medicinal Science, Wonkwang University, Chonbuk, 570-749, Iksan City, South Korea.

出版信息

Clin Chim Acta. 2001 Oct;312(1-2):163-8. doi: 10.1016/s0009-8981(01)00613-1.

DOI:10.1016/s0009-8981(01)00613-1

PMID:11580922

Abstract

BACKGROUND

Mast cells synthesize and secrete chemical mediators which play a central role in anaphylaxis.

METHODS

The effect of Acanthopanax senticosus root (ASR) on mast cell-dependent anaphylaxis was investigated.

RESULTS

ASR inhibited compound 48/80-induced systemic anaphylactic shock at the dose of 1.0 g/kg by 50%. When ASR was given as pre-treatment at concentrations ranging from 0.01 to 2.0 g/l, the histamine release from rat peritoneal mast cells induced by compound 48/80 was reduced in a dose-dependent manner. ASR (2.0 g/kg) also inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE to 53.17+/-6.62%. Moreover, ASR inhibited tumor necrosis factor-alpha production in a concentration-dependent manner, and the treatment of 1 g/l blocked the production by 32.5+/-3.50% compared to saline value.