Feresin G E, Tapia A, López S N, Zacchino S A
Instituto de Biotecnología. Universidad Nacional de San Juan, Avda. Libertador General San Martín 1109 (O), 5400, San Juan, Argentina.
J Ethnopharmacol. 2001 Nov;78(1):103-7. doi: 10.1016/s0378-8741(01)00322-1.
Eighteen extracts from Acaena magellanica, Baccharis grisebachii, Ephedra breana, Oxalis erythrorhiza, Pachylaena atriplicifolia and Satureja parvifolia were assessed for antimicrobial activity against bacteria and fungi with the agar dilution method. The hexane (H) and dichloromethane (DCM) extracts of B. grisebachii and O. erythrorhiza showed the broadest spectrum of action against fungi, inhibiting all of the tested dermatophytes with MICs ranging from < or =25 to < or =1000 microg/ml. Trichophyton rubrum was the most susceptible species and Cryptococcus neoformans was inhibited only by the DCM extract of B. grisebachii with MIC of 600 microg/ml. Regarding the antibacterial activity, H and DCM extracts of B. grisebachii as well as the DCM of O. erythrorhiza, were active on methicillin-resistant and methicillin-sensitive Staphylococcus aureus with MIC from < or =125 to < or =500 microg/ml. The DCM extract of B. grisebacchii was more active against methicillin-resistant than methicillin-sensitive strains.
采用琼脂稀释法，对取自麦哲伦刺苞果、灰枝巴卡草、短麻黄、红叶酢浆草、厚叶藜和小叶风轮菜的18种提取物进行了抗细菌和真菌的抗菌活性评估。灰枝巴卡草和红叶酢浆草的己烷（H）提取物和二氯甲烷（DCM）提取物对真菌表现出最广的抗菌谱，抑制了所有测试的皮肤癣菌，其最低抑菌浓度（MIC）范围为≤25至≤1000微克/毫升。红色毛癣菌是最敏感的菌种，新型隐球菌仅被灰枝巴卡草的DCM提取物抑制，MIC为600微克/毫升。关于抗菌活性，灰枝巴卡草的H提取物和DCM提取物以及红叶酢浆草的DCM提取物对耐甲氧西林金黄色葡萄球菌和甲氧西林敏感金黄色葡萄球菌有活性，MIC为≤125至≤500微克/毫升。灰枝巴卡草的DCM提取物对耐甲氧西林菌株的活性比对甲氧西林敏感菌株的活性更强。
