Stücker M, Memmel U, Hoffmann M, Hartung J, Altmeyer P
Department of Dermatology and Allergology, Ruhr University, Bochum, Germany.
Dermatology. 2001;203(2):141-7. doi: 10.1159/000051729.
There are already many effective topical therapies available for use in the treatment of chronic plaque psoriasis. Unfortunately, these treatments are often associated with a rather significant risk of undesirable effects.
In this randomized, prospective clinical trial, the effects of the vitamin D(3) analog calcipotriol were evaluated against those of a recently developed vitamin B(12) cream containing avocado oil in an intraindividual right/left-side comparison. The trial population consisted of 13 patients, 10 men and 3 women, with chronic plaque psoriasis. The observation period was 12 weeks; the effects of therapy were assessed on the basis of a PASI score adapted to the right/left-side comparison technique, the subjective evaluations of the investigator and patients and the results of 20-MHz sonography.
There was a more rapid development of beneficial effects with the use of calcipotriol in the initial 8 weeks, although differences in effects were significant only at the time point of therapy week 8 (p < 0.05). After 12 weeks, neither the PASI score nor 20-MHz sonography showed significant differences between the two treatments. While the efficacy of the calcipotriol preparation reached a maximum in the first 4 weeks and then began to subside, the effects of the vitamin B(12) cream containing avocado oil remained at a constant level over the whole observation period. This would indicate that the vitamin B(12) preparation containing avocado oil may be suitable for use in long-term therapy, a hypothesis further supported by the fact that the investigator and the patients assessed the tolerability of the vitamin B(12) cream containing avocado oil as significantly better in comparison with that of calcipotriol.
The results of this clinical trial provide evidence that the recently developed vitamin B(12) cream containing avocado oil has considerable potential as a well-tolerated, long-term topical therapy of psoriasis.
目前已有多种有效的局部治疗方法可用于慢性斑块状银屑病的治疗。不幸的是，这些治疗方法常常伴有相当显著的不良反应风险。
在这项随机、前瞻性临床试验中，通过个体右侧/左侧对照，评估维生素D(3)类似物卡泊三醇与最近研发的含鳄梨油的维生素B(12)乳膏的疗效。试验人群包括13例慢性斑块状银屑病患者，其中男性10例，女性3例。观察期为12周；根据适用于右侧/左侧对照技术的银屑病面积和严重程度指数（PASI）评分、研究者和患者的主观评估以及20兆赫兹超声检查结果评估治疗效果。
在最初8周使用卡泊三醇时有益效果出现得更快，尽管仅在治疗第8周时效果差异具有统计学意义（p < 0.05）。12周后，两种治疗方法在PASI评分和20兆赫兹超声检查方面均未显示出显著差异。卡泊三醇制剂的疗效在最初4周达到最大值，然后开始下降，而含鳄梨油的维生素B(12)乳膏的效果在整个观察期内保持稳定。这表明含鳄梨油的维生素B(12)制剂可能适用于长期治疗，研究者和患者评估含鳄梨油的维生素B(12)乳膏的耐受性明显优于卡泊三醇这一事实进一步支持了这一假设。
这项临床试验结果表明，最近研发的含鳄梨油的维生素B(12)乳膏作为一种耐受性良好的银屑病长期局部治疗方法具有相当大的潜力。
