Kimberlin R H, Marsh R F
J Infect Dis. 1975 Feb;131(2):97-103. doi: 10.1093/infdis/131.2.97.
A series of 15 different biochemical measurements were made on brains taken at stages throughout the development of scrapie and of transmissible mink encephalopathy in hamsters. With both diseases biochemical abnormalities were found only after the development of early histologic lesions, when animals showed clinical signs of disease. Changes were recorded in body weight, in the activities of six glycosidases, and the rates of incorporation of DNA and of glycoprotein precursors. The profiles of changes in hamster brain were almost indistinguishable,qualitatively and quantitatively, in the two diseases, an observation suggesting a close similarity in the way both disease-producing agents interact with this particular host species, . However, there were some major differences between the profile of changes in hamster scrapie and that previously observed in mouse scrapie. Thus it would appear that many of the well-characterized abnormalities of mouse scrapie are not fundamentally involved in the development of disease but represent mainly secondary changes.
对在仓鼠瘙痒病和传染性水貂脑病整个发育阶段采集的大脑进行了一系列15种不同的生化测定。在这两种疾病中，只有在早期组织学病变出现后，动物出现疾病临床症状时，才发现生化异常。记录了体重、六种糖苷酶的活性以及DNA和糖蛋白前体的掺入率的变化。在这两种疾病中，仓鼠大脑的变化特征在质量和数量上几乎无法区分，这一观察结果表明，两种致病因子与这种特定宿主物种相互作用的方式非常相似。然而，仓鼠瘙痒病的变化特征与之前在小鼠瘙痒病中观察到的变化特征存在一些主要差异。因此，似乎小鼠瘙痒病中许多特征明确的异常并非疾病发展的根本原因，而主要是继发性变化。
