Schäfer E, Bossmann K
Poliklinik für Zahnerhaltung, Westälische Wilhelms-Universität, Münster, Germany.
Am J Dent. 2001 Aug;14(4):233-7.
To investigate the antimicrobial efficacy of a chlorhexidine gluconate (2.0%) and of an ethanolic chloroxylenol solution (10%) as a temporary root canal dressing against selected test microorganisms (Staphylococcus aureus, Streptococcus faecium, Escherichia coli, Candida albicans).
Extracted single-rooted human teeth were instrumented up to size 40. After removal of the smear layer suspensions of the test microorganisms were inserted into the root canals. After incubation for 48 hrs each suspension of the test organisms was removed and the root canals were filled with one of the two different disinfectants. The teeth were then incubated for 48 hrs. Twelve teeth and three controls were used for each of the four test organisms and each of the two regimens. After incubation, each root canal was instrumented and the removed canal wall dentin was examined microbiologically.
With a contact time of 48 hrs between the two disinfectants and the four bacterial suspensions the medications led to a total killing of microorganisms in 82% of a total of 96 contaminated teeth. In the dentin layer situated 50 microm from the root canal, both medications achieved bacterial killing in a range from 99.9% to 99.99%, depending on the test organism. There were no significant differences (P> 0.1) between the relative antimicrobial activity of the two root canal dressings.
研究葡萄糖酸洗必泰（2.0%）和乙醇氯二甲酚溶液（10%）作为临时根管充填材料对所选测试微生物（金黄色葡萄球菌、粪肠球菌、大肠杆菌、白色念珠菌）的抗菌效果。
将拔除的单根人牙预备至40号。去除玷污层后，将测试微生物的悬液注入根管。孵育48小时后，去除每种测试微生物的悬液，并用两种不同的消毒剂之一充填根管。然后将牙齿再孵育48小时。针对四种测试微生物中的每一种以及两种治疗方案中的每一种，使用12颗牙齿和3颗对照牙。孵育后，对每个根管进行预备，并对取出的根管壁牙本质进行微生物学检查。
两种消毒剂与四种细菌悬液接触48小时后，在总共96颗受污染的牙齿中，82%的牙齿中的微生物被全部杀灭。在距根管50微米处的牙本质层中，根据测试微生物的不同，两种药物的杀菌率在99.9%至99.99%之间。两种根管充填材料的相对抗菌活性之间无显著差异（P>0.1）。
