Annett R D, Bender B G, Lapidus J, Duhamel T R, Lincoln A
Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM 87131-5311, USA.
J Pediatr. 2001 Dec;139(6):854-61. doi: 10.1067/mpd.2001.119444.
To define predictors of disease-specific quality of life (QOL) and the relationship between asthma symptoms and disease-specific QOL.
Three hundred thirty-nine children participated at 4 of 8 Childhood Asthma Management Program clinical centers. Included in the analyses were 2 weeks of asthma symptom data, child-reported health status, and QOL scores from the Pediatric Asthma Quality of Life Questionnaire. Data were obtained 12 months after randomization into the Childhood Asthma Management Program.
Children were rated at baseline as having "moderate" asthma (63%) and "mild" asthma (37%). QOL scores were correlated with the child-reported anxiety measures. Factor analysis of the QOL measure resulted in 2 factors. Stepwise multiple regression indicated that the strongest independent predictors of QOL were the child's anxiety level, age, sex, and a measure of the child's tendency to minimize or exaggerate symptoms.
Children had few asthma symptoms in the 2 weeks before their 12-month follow-up clinic visit and a generally positive QOL, suggesting that mild-to-moderate asthma does not significantly impair QOL. A child's QOL was predicted primarily by their level of anxiety.
确定疾病特异性生活质量（QOL）的预测因素以及哮喘症状与疾病特异性生活质量之间的关系。
339名儿童参与了8个儿童哮喘管理项目临床中心中的4个中心的研究。纳入分析的有2周的哮喘症状数据、儿童报告的健康状况以及来自儿童哮喘生活质量问卷的生活质量评分。这些数据是在随机分组进入儿童哮喘管理项目12个月后获得的。
儿童在基线时被评定为患有“中度”哮喘（63%）和“轻度”哮喘（37%）。生活质量评分与儿童报告的焦虑测量值相关。对生活质量测量进行因子分析得出2个因子。逐步多元回归表明，生活质量的最强独立预测因素是儿童的焦虑水平、年龄、性别以及儿童对症状最小化或夸大的倾向测量值。
在12个月随访门诊就诊前的2周内，儿童哮喘症状较少，生活质量总体呈阳性，这表明轻度至中度哮喘不会显著损害生活质量。儿童的生活质量主要由其焦虑水平预测。
