Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Qual Life Res. 2010 Dec;19(10):1517-27. doi: 10.1007/s11136-010-9715-4. Epub 2010 Aug 1.
To determine factors associated with 24-month change in quality of life in children with asthma and their parents during the Childhood Asthma Management Program (CAMP).
Participants from 4 CAMP clinical centers were administered the Pediatric Asthma Quality of Life questionnaire and protocol measures of asthma symptoms, lung function, and psychological measures.
Multivariate logistic regression analyses determined predictors of moderate change in quality of life. Subclinical levels of depression predicted moderate improvement in child-reported quality of life. Level of depressed affect together with clinical asthma features predicted moderate decline. Improvement in parent quality of life was predicted by perception of illness burden, whereas family features and a child missing school predicted moderate decline.
This ancillary study provided an opportunity to examine the determinants of 24-month change in parent and child of quality of life within a subset of the CAMP participants. Moderate changes in quality of life occur in clinical studies and have both psychosocial correlates and illness characteristics.
在儿童哮喘管理计划（CAMP）期间，确定与哮喘儿童及其父母 24 个月生活质量变化相关的因素。
来自 4 个 CAMP 临床中心的参与者接受了儿科哮喘生活质量问卷以及哮喘症状、肺功能和心理测量的方案措施。
多变量逻辑回归分析确定了生活质量中度变化的预测因素。亚临床水平的抑郁预测儿童报告的生活质量中度改善。抑郁情绪水平与临床哮喘特征共同预测了中度下降。父母生活质量的改善与疾病负担的感知有关，而家庭特征和孩子缺课则预测了中度下降。
这项辅助研究提供了一个机会，在 CAMP 参与者的一个亚组中，检验父母和孩子 24 个月生活质量变化的决定因素。生活质量的中度变化发生在临床研究中，具有社会心理相关性和疾病特征。
