Matos H R, Capelozzi V L, Gomes O F, Mascio P D, Medeiros M H
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, CP 26077, CEP 05513-970 São Paulo, SP, Brazil.
Arch Biochem Biophys. 2001 Dec 15;396(2):171-7. doi: 10.1006/abbi.2001.2611.
Experimental and epidemiological evidence suggests that lycopene, a carotenoid present in tomatoes, tomato products, and several fruits and vegetables, may play a role in preventing certain cancers in humans. We have investigated the effect of lycopene pretreatment on lipid peroxidation, oxidative damage to DNA, and histopathological changes in liver of animals subjected to intraperitoneal (ip) ferric nitrilotriacetate (Fe-NTA) administration. Compared with control rats, liver of Fe-NTA-treated animals showed a significant increase in the 8-oxo-7,8-dihydro-2'-deoxyguanosine level and a 75% increase in malondialdehyde accumulation concomitant with histopathological changes. Five days of lycopene pretreatment (10 mg/kg body weight, ip) almost completely prevented liver biomolecule oxidative damage and protected the tissue against the observed histological alterations.
实验和流行病学证据表明，番茄红素这种存在于番茄、番茄制品以及多种水果和蔬菜中的类胡萝卜素，可能在预防人类某些癌症方面发挥作用。我们研究了番茄红素预处理对腹腔注射次氮基三乙酸铁（Fe-NTA）的动物肝脏脂质过氧化、DNA氧化损伤及组织病理学变化的影响。与对照大鼠相比，接受Fe-NTA处理的动物肝脏中8-氧代-7,8-二氢-2'-脱氧鸟苷水平显著升高，丙二醛积累增加75%，同时伴有组织病理学变化。番茄红素预处理5天（10毫克/千克体重，腹腔注射）几乎完全防止了肝脏生物分子的氧化损伤，并保护组织免受观察到的组织学改变。
