Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, UK.
Database (Oxford). 2012 Apr 15;2012:bas019. doi: 10.1093/database/bas019. Print 2012.
The PRINTS database, now in its 21st year, houses a collection of diagnostic protein family 'fingerprints'. Fingerprints are groups of conserved motifs, evident in multiple sequence alignments, whose unique inter-relationships provide distinctive signatures for particular protein families and structural/functional domains. As such, they may be used to assign uncharacterized sequences to known families, and hence to infer tentative functional, structural and/or evolutionary relationships. The February 2012 release (version 42.0) includes 2156 fingerprints, encoding 12 444 individual motifs, covering a range of globular and membrane proteins, modular polypeptides and so on. Here, we report the current status of the database, and introduce a number of recent developments that help both to render a variety of our annotation and analysis tools easier to use and to make them more widely available. Database URL: www.bioinf.manchester.ac.uk/dbbrowser/PRINTS/.
PRINTS 数据库现已进入第 21 个年头，其中包含了一系列诊断蛋白家族“指纹”。指纹是在多个序列比对中明显存在的保守基序组，其独特的相互关系为特定的蛋白质家族和结构/功能域提供了独特的特征。因此，它们可用于将未鉴定的序列分配到已知家族，并由此推断出暂定的功能、结构和/或进化关系。2012 年 2 月发布的版本（42.0）包括 2156 个指纹，编码 12444 个单独的基序，涵盖了一系列球状和膜蛋白、模块化多肽等。在这里，我们报告了数据库的当前状态，并介绍了一些最近的发展，这些发展有助于使我们的各种注释和分析工具更易于使用，并更广泛地提供这些工具。数据库网址：www.bioinf.manchester.ac.uk/dbbrowser/PRINTS/。
