Ruzibakiev R, Kato H, Ueda R, Yuldasheva N, Hegay T, Avazova D, Kurbanov F, Zalalieva M, Tuichiev L, Achundjanov B, Mizokami M
Institute of Immunology, Academy of Science, Tashkent, Uzbekistan.
Intervirology. 2001;44(6):327-32. doi: 10.1159/000050066.
The aim of this study was to elucidate the seroprevalence of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infection in Uzbekistan and to explore whether there is a correlation between those blood-borne agents and socioeconomic risk factors.
One thousand nine hundred and eighteen subjects were studied. The subjects were divided into a low-risk group, a high-risk group and a patient group. Sera were tested for HBV surface antigen (HBsAg), anti-HCV, and anti-HIV.
The seroprevalence of HBsAg, anti-HCV, and anti-HIV in the general population was 13.3, 13.1 and 0%, respectively. The anti-HCV infection rate was significantly higher in intravenous drug users (62.7%) than in prostitutes (9.2%), homosexuals (11.1%), and medical laboratory employees (12.5%) (p < 0.01). In the low-risk group, positivity for anti-HCV increased with age from 2.2% in the 15- to 20-year-olds up to the highest rate of 17.6% in the 31- to 40-year-olds; the positivity then decreased to 0% in the group over 60 years of age. In the high-risk group, the positivity for anti-HCV in the age groups under 40 years was approximately 30% and significantly higher than in the low-risk group (p < 0.01). Risk factors for transmission of HCV were medical treatment in the low-risk group, drug abuse in the high-risk group, and both in the patient group.
This study demonstrates that the seroprevalence of HBV and HCV infection is high, whereas HIV infection is yet uncommon in Uzbekistan.
本研究旨在阐明乌兹别克斯坦乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）和人类免疫缺陷病毒（HIV）感染的血清流行率，并探讨这些血源性病原体与社会经济风险因素之间是否存在相关性。
对1918名受试者进行了研究。受试者被分为低风险组、高风险组和患者组。检测血清中的HBV表面抗原（HBsAg）、抗-HCV和抗-HIV。
普通人群中HBsAg、抗-HCV和抗-HIV的血清流行率分别为13.3%、13.1%和0%。静脉吸毒者的抗-HCV感染率（62.7%）显著高于妓女（9.2%）、同性恋者（11.1%）和医学实验室工作人员（12.5%）（p<0.01）。在低风险组中，抗-HCV阳性率随年龄增长而增加，从15至20岁组的2.2%上升至31至40岁组的最高率17.6%；然后在60岁以上组中降至0%。在高风险组中，40岁以下年龄组的抗-HCV阳性率约为30%，显著高于低风险组（p<0.01）。HCV传播的风险因素在低风险组为医疗治疗，在高风险组为药物滥用，在患者组为两者皆有。
本研究表明，在乌兹别克斯坦，HBV和HCV感染的血清流行率较高，而HIV感染尚不常见。
