Monarca Silvano, Richardson Susan D, Feretti Donatella, Grottolo Mario, Thruston Alfred D, Zani Claudia, Navazio Giancarlo, Ragazzo Patrizia, Zerbini Ilaria, Alberti Adriana
Department of Experimental and Applied Medicine, University of Brescia, Italy.
Environ Toxicol Chem. 2002 Feb;21(2):309-18.
The aims of this research were to study the influence of peracetic acid (PAA) on the formation of mutagens in surface waters used for human consumption and to assess its potential application for the disinfection of drinking water. The results obtained using PAA were compared to those found with sodium hypochlorite (NaClO) and chlorine dioxide (ClO2). The Ames test, root anaphase aberration assay, and root/micronuclei assay in Allium cepa and Tradescantia/micronuclei test were used to evaluate the mutagenicity of disinfected samples. Microbiological tests were also performed, and disinfection by-products (DBPs) were identified using gas chromatography/mass spectrometry (GC/MS). A slight bacterial mutagenicity was found in raw lake and river water, and similar activity was detected in disinfected samples. A plant test revealed genotoxicity in raw river water, and microbiological analysis showed that PAA has bactericidal activity but lower than that of the other disinfectants. The DBPs produced by PAA were mainly carboxylic acids, which are not recognized as mutagenic, whereas the waters treated with the other disinfectants showed the presence of mutagenic/carcinogenic halogenated DBPs. However, additional experiments should be performed with higher concentrations of PAA and using water with higher organic carbon content to better evaluate this disinfectant.
本研究的目的是研究过氧乙酸（PAA）对供人类饮用的地表水中诱变剂形成的影响，并评估其在饮用水消毒中的潜在应用。将使用PAA获得的结果与使用次氯酸钠（NaClO）和二氧化氯（ClO2）获得的结果进行比较。采用艾姆斯试验、根尖后期畸变试验、洋葱根尖/微核试验和紫露草/微核试验评估消毒后样品的致突变性。还进行了微生物学试验，并使用气相色谱/质谱联用仪（GC/MS）鉴定消毒副产物（DBPs）。在未经处理的湖水和河水中发现了轻微的细菌致突变性，在消毒后的样品中也检测到了类似的活性。一项植物试验显示未经处理的河水中存在遗传毒性，微生物学分析表明PAA具有杀菌活性，但低于其他消毒剂。PAA产生的消毒副产物主要是羧酸，不被认为具有致突变性，而用其他消毒剂处理的水中则存在具有致突变性/致癌性的卤代消毒副产物。然而，应该使用更高浓度的PAA并使用有机碳含量更高的水进行额外的实验，以更好地评估这种消毒剂。
