Friedman P M, Mafong E A, Friedman E S, Geronemus R G
Derm Surgery Associates, Houston, Texas 77030, USA.
Dermatol Surg. 2001 Dec;27(12):1019-26. doi: 10.1046/j.1524-4725.2001.01855.x.
Topical anesthetics remain a powerful, new advance for pain relief prior to cutaneous procedures. They are frequently used by dermatologists to decrease the pain associated with laser pulses, surgical procedures, or soft tissue augmentation. EMLA is the most commonly used agent, however, several new topical anesthetic agents have been released recently that claim increased efficacy and a faster onset of action.
We review and compare the efficacy of several commonly used topical anesthetics and provide a look into the future.
EMLA remains the most widely used topical anesthetic given its proven efficacy and safety by several clinical trials. There has been a recent release of several new topical anesthetic agents with some demonstrating efficacy after a 30-minute application time. A reservoir of anesthetic is located and stored in the upper skin layers during application, providing additional anesthetic benefit 30 minutes after removal. As the options for the practitioner continue to grow, the demand for faster onset, comparative efficacy, and safety trials will continue to be of paramount importance.
局部麻醉剂仍然是皮肤手术前缓解疼痛的一项有力的新进展。皮肤科医生经常使用它们来减轻与激光脉冲、外科手术或软组织填充相关的疼痛。EMLA是最常用的药物，然而，最近有几种新的局部麻醉剂上市，它们声称具有更高的疗效和更快的起效时间。
我们回顾并比较几种常用局部麻醉剂的疗效，并展望未来。
鉴于多项临床试验已证实其疗效和安全性，EMLA仍然是使用最广泛的局部麻醉剂。最近有几种新的局部麻醉剂上市，其中一些在应用30分钟后显示出疗效。在应用过程中，麻醉剂储存在皮肤上层，去除后30分钟仍能提供额外的麻醉效果。随着从业者的选择不断增加，对更快起效、比较疗效和安全性试验的需求将继续至关重要。
