Echeverria P, Siber G R, Paisley J, Smith A L, Smith D H, Jaffe N, Paed D
J Pediatr. 1975 Nov;87(5):805-8. doi: 10.1016/s0022-3476(75)80316-7.
Serum gentamicin concentrations were measured 30 minutes after 140 intravenous doses in 60 children and nine adults with normal renal function. Distinct interpatient variation was observed but individual patients tended to have similar pharmacokinetics with repeated doses. Age had a significant effect in that mean peak serum concentrations were 1.58 mug/ml per 1 mg/kg dose in children between 6 months and 5 years, 2.03 mug/ml per 1 mg/kg in those between 5 and 10, and 2.86 mug/ml per 1 mg/kg in children 10 to 15 years of age. The mean calculated single dose of gentamicin necessary to achieve a peak serum concentration between 4 and 5 mug/ml is 2.5 mg/kg for ages 0.5 to 5 years, 2.0 mg/kg for ages 5 to 10 years, and 1.5 mg/kg for individuals over 10 years of age.
对60名儿童和9名肾功能正常的成年人静脉注射140次剂量后30分钟测量血清庆大霉素浓度。观察到患者之间存在明显差异，但个体患者多次给药后药代动力学倾向于相似。年龄有显著影响，6个月至5岁儿童每1mg/kg剂量的平均血清峰值浓度为1.58μg/ml，5至10岁儿童为2.03μg/ml，10至15岁儿童为2.86μg/ml。对于0.5至5岁的儿童，要达到4至5μg/ml的血清峰值浓度，所需的平均计算单次庆大霉素剂量为2.5mg/kg；5至10岁为2.0mg/kg；10岁以上个体为1.5mg/kg。
