Friedman Paul M, Skover Greg R, Payonk Greg, Kauvar Arielle N B, Geronemus Roy G
Laser and Skin Surgery Center of New York, New York, NY, USA.
Dermatol Surg. 2002 Mar;28(3):199-204. doi: 10.1046/j.1524-4725.2002.02832.x.
A new method for treating facial rhytides and acne scars with nonablative laser and light source techniques has recently been introduced. Given the inherent limitations of photographic and clinical evaluation to assess subtle changes in rhytides and surface topography, a new noninvasive objective assessment is required to accurately assess the outcomes of these procedures.
The purpose of this study was to measure and objectively quantify facial skin using a novel, noninvasive, In-vivo method for assessing three-dimensional topography. This device was used to quantify the efficacy of five treatment sessions with the 1064 nm QS Nd:YAG laser for rhytides and acne scarring, for up to six months following laser treatment.
Two subjects undergoing facial rejuvenation procedures were analyzed before and after therapy using a 30-mm, three-dimensional microtopography imaging system (PRIMOS, GFM, Teltow, Germany). The imaging system projects light on to a specific surface of the skin using a Digital Micromirror Device (DMD Texas Instruments, Irving, TX) and records the image with a CCD camera. Skin Surface microtopography is reconstructed using temporal phase shift algorithms to generate three-dimensional images. Measurements were taken at baseline, at various times during the treatment protocol, and then at three and six-month follow-up visits. Silicone skin replicas (FLEXICO, Herts, England) were also made before and after the laser treatment protocol for comparison to In-vivo acquisition.
Skin roughness decreased by 11% from baseline after three treatment sessions in the wrinkles subject, while a 26% improvement of skin roughness was recorded by 3D In-vivo assessment six months following the fifth treatment session. The subject with acne scarring demonstrated a 33% decrease in roughness analysis after three treatment sessions by 3D In-vivo assessment. A 61% improvement in surface topography was recorded 3-months following the fifth treatment session, which was maintained at the 6-month follow-up.
Three-dimensional In-vivo optical skin imaging provided a rapid and quantitative assessment of surface topography and facial fine lines following multiple treatment sessions with a 1064-nm QS Nd:YAG laser, correlating with clinical and subjective responses. This imaging technique provided objective verification and technical understanding of nonablative laser technology. Wrinkle depth and skin roughness decreased at the three and six-month follow-up evaluations by 3D In-vivo assessment, indicating ongoing dermal collagen remodeling after the laser treatment protocol. Future applications may include comparison of nonablative laser technology, optimization of treatment regimens, and objective evaluation of other aesthetic procedures performed by dermatologists.
最近引入了一种使用非剥脱性激光和光源技术治疗面部皱纹和痤疮疤痕的新方法。鉴于摄影和临床评估在评估皱纹和表面形貌细微变化方面存在固有局限性，需要一种新的非侵入性客观评估方法来准确评估这些治疗程序的效果。
本研究的目的是使用一种新颖的、非侵入性的体内方法来测量和客观量化面部皮肤的三维形貌。该设备用于量化1064nm调Q Nd:YAG激光五次治疗对面部皱纹和痤疮疤痕的疗效，随访期长达激光治疗后六个月。
使用30毫米三维微观形貌成像系统（PRIMOS，GFM，德国特尔托夫）对两名接受面部年轻化治疗的受试者在治疗前后进行分析。该成像系统使用数字微镜器件（德州仪器公司，得克萨斯州欧文市）将光投射到皮肤的特定表面，并用电荷耦合器件相机记录图像。使用时间相移算法重建皮肤表面微观形貌以生成三维图像。在基线、治疗方案的不同时间点以及治疗后三个月和六个月的随访时进行测量。在激光治疗方案前后还制作了硅胶皮肤复制品（FLEXICO，英国赫特福德郡），以便与体内采集的数据进行比较。
皱纹受试者在三次治疗后，皮肤粗糙度较基线下降了11%，而在第五次治疗后六个月的三维体内评估中，皮肤粗糙度改善了26%。痤疮疤痕受试者在三维体内评估中，三次治疗后粗糙度分析下降了33% 在第五次治疗后三个月，表面形貌改善了61%，在六个月随访时保持这一改善水平。
三维体内光学皮肤成像为1064nm调Q Nd:YAG激光多次治疗后的表面形貌和面部细纹提供了快速定量评估，与临床和主观反应相关。这种成像技术为非剥脱性激光技术提供了客观验证和技术理解。在三维体内评估的三个月和六个月随访评估中，皱纹深度和皮肤粗糙度下降，表明激光治疗方案后真皮胶原蛋白持续重塑。未来的应用可能包括非剥脱性激光技术的比较、治疗方案的优化以及皮肤科医生进行的其他美容手术的客观评估。
